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Literature summary extracted from
- Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis (2012), Dev. Biol., 362, 263-270.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.13 | Danio rerio | Q7ZZK6 | alpha subunit isoform 1 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.13 | atp1a1a | - |
Danio rerio |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.2.2.13 | physiological function | function of Na+,K+ ATPase Atp1a1 in the elongation of the zebrafish heart tube. Embryos lacking Atp1a1 function exhibit abnormal migration behavior of cardiac precursors, defects in the elongation of the heart tube, and a severe reduction in extracellular matrix/fibronectin deposition around the myocardium. Atp1a1 is expressed in an extraembryonic tissue, the yolk syncytial layer, at earlier stages. Knockdown of Atp1a1 activity specifically in the yolk syncytial layer produces heart tube elongation defects like those found in atp1a1 mutants | Danio rerio |
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Release 2023.1 (January 2023)
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