BRENDA - Enzyme Database show

Drug transport via the intestinal peptide transporter PepT1

Brandsch, M.; Curr. Opin. Pharmacol. 13, 881-887 (2013)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.4.2.5
Homo sapiens
-
-
-
7.4.2.5
Mus musculus
-
-
-
7.4.2.5
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
7.4.2.5
biliary duct
-
Mus musculus
-
7.4.2.5
intestine
-
Homo sapiens
-
7.4.2.5
intestine
-
Rattus norvegicus
-
7.4.2.5
intestine
-
Mus musculus
-
7.4.2.5
kidney
-
Mus musculus
-
7.4.2.5
nasal epithelium
-
Mus musculus
-
7.4.2.5
prostate cancer cell
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Mus musculus
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Homo sapiens
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Rattus norvegicus
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Mus musculus
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Homo sapiens
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Rattus norvegicus
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Mus musculus
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Homo sapiens
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Rattus norvegicus
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Mus musculus
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Homo sapiens
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Rattus norvegicus
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Mus musculus
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Homo sapiens
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Rattus norvegicus
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Mus musculus
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Homo sapiens
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Rattus norvegicus
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Mus musculus
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Homo sapiens
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Rattus norvegicus
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Mus musculus
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Homo sapiens
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Rattus norvegicus
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Mus musculus
ADP + phosphate + Zan-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Homo sapiens
ADP + phosphate + Zan-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Rattus norvegicus
ADP + phosphate + Zan-L-Val/out
-
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
7.4.2.5
biliary duct
-
Mus musculus
-
7.4.2.5
intestine
-
Homo sapiens
-
7.4.2.5
intestine
-
Rattus norvegicus
-
7.4.2.5
intestine
-
Mus musculus
-
7.4.2.5
kidney
-
Mus musculus
-
7.4.2.5
nasal epithelium
-
Mus musculus
-
7.4.2.5
prostate cancer cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Mus musculus
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Homo sapiens
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + cefadroxil/in
preferable substrate
733688
Rattus norvegicus
ADP + phosphate + cefadroxil/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Mus musculus
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Homo sapiens
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + D-phenylglycine-L-Dopa/in
-
733688
Rattus norvegicus
ADP + phosphate + D-phenylglycine-L-Dopa/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Mus musculus
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Homo sapiens
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + delta-aminolevulinic acid/in
-
733688
Rattus norvegicus
ADP + phosphate + delta-aminolevulinic acid/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Mus musculus
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Homo sapiens
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + guanidine oseltamivir carboxylate-L-Val/in
-
733688
Rattus norvegicus
ADP + phosphate + guanidine oseltamivir carboxylate-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Mus musculus
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Homo sapiens
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + JBP485/in
JBP485 is cyclo-trans-4-L-hydroxyprolyl-L-serine
733688
Rattus norvegicus
ADP + phosphate + JBP485/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Mus musculus
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Homo sapiens
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + L-Val-didanosine/in
didanosine is also named Videx or 5'-O-2'-3'-dideoxydidanosine
733688
Rattus norvegicus
ADP + phosphate + L-Val-didanosine/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Mus musculus
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Homo sapiens
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + NP-647/in
NP-647 is L-pGlu-(2-propyl)-L-His-L-ProNH2
733688
Rattus norvegicus
ADP + phosphate + NP-647/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Mus musculus
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Homo sapiens
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + valacyclovir/in
-
733688
Rattus norvegicus
ADP + phosphate + valacyclovir/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Mus musculus
ADP + phosphate + Zan-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Homo sapiens
ADP + phosphate + Zan-L-Val/out
-
-
-
?
7.4.2.5
ATP + H2O + Zan-L-Val/in
-
733688
Rattus norvegicus
ADP + phosphate + Zan-L-Val/out
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
7.4.2.5
malfunction
enzyme ablation results in 3-5fold reduction in the in vivo rate and extent of valacyclovir absorption
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
7.4.2.5
malfunction
enzyme ablation results in 3-5fold reduction in the in vivo rate and extent of valacyclovir absorption
Mus musculus