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Literature summary extracted from

  • Shimizu, A.; Handa, K.; Honda, T.; Abe, N.; Kojima, T.; Takahara, H.
    Three isozymes of peptidylarginine deiminase in the chicken: molecular cloning, characterization, and tissue distribution (2014), Comp. Biochem. Physiol. B, 167, 65-73.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.15 expressed in Sf21 insect cells Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ dependent on Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.3.15 73700
-
 x * 73700, isoform PAD1, SDS-PAGE Gallus gallus
3.5.3.15 74200
-
 x * 74200, isoform PAD2, SDS-PAGE Gallus gallus
3.5.3.15 74500
-
 x * 74500, isoform PAD3, SDS-PAGE Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein L-arginine + H2O Gallus gallus
-
 protein L-citrulline + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Gallus gallus E1C0W6 isoform PAD1
-
3.5.3.15 Gallus gallus F1NP39 isoform PAD3
-
3.5.3.15 Gallus gallus S6BNL5 isoform PAD2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.15 HisTrap column chromatography Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.3.15 cerebellum
-
 Gallus gallus
-
3.5.3.15 cerebrum
-
 Gallus gallus
-
3.5.3.15 gizzard
-
 Gallus gallus
-
3.5.3.15 glandular stomach
-
 Gallus gallus
-
3.5.3.15 heart
-
 Gallus gallus
-
3.5.3.15 liver
-
 Gallus gallus
-
3.5.3.15 lung
-
 Gallus gallus
-
3.5.3.15 additional information isoform PAD2 protein is not detected in lung, heart, liver, granular stomach, and gizzard Gallus gallus
-
3.5.3.15 muscle
-
 Gallus gallus
-
3.5.3.15 optic lobe
-
 Gallus gallus
-
3.5.3.15 retina
-
 Gallus gallus
-
3.5.3.15 spinal cord
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 L-arginine-methyl ester + H2O isoform PAD1 shows 15% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus L-citrulline methyl ester + NH3
-
 ?
3.5.3.15 L-arginine-methyl ester + H2O isoform PAD3 shows 15% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus L-citrulline methyl ester + NH3
-
 ?
3.5.3.15 additional information no activity with L-arginine Gallus gallus ?
-
 ?
3.5.3.15 N-acetyl-L-arginine + H2O isoform PAD1 shows 160% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus N-acetyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 N-acetyl-L-arginine + H2O isoform PAD3 shows 135% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus N-acetyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 N-acetyl-L-arginine-methyl ester + H2O isoform PAD1 shows 80% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus N-acetyl-L-citrulline-methyl ester + NH3
-
 ?
3.5.3.15 N-acetyl-L-arginine-methyl ester + H2O isoform PAD3 shows 125% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus N-acetyl-L-citrulline-methyl ester + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine + H2O isoform PAD1 shows 120% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-benzoyl-L-citrulline + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine + H2O isoform PAD3 shows 70% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-benzoyl-L-citrulline + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine ethyl ester + H2O 100% activity Gallus gallus Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine-amide + H2O isoform PAD1 shows 110% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-benzoyl-L-citrulline-amide + NH3
-
 ?
3.5.3.15 Nalpha-benzoyl-L-arginine-amide + H2O isoform PAD3 shows 105% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-benzoyl-L-citrulline-amide + NH3
-
 ?
3.5.3.15 Nalpha-tosyl-L-arginine-methyl ester + H2O isoform PAD1 shows 20% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-tosyl-L-citrulline-methyl ester + NH3
-
 ?
3.5.3.15 Nalpha-tosyl-L-arginine-methyl ester + H2O isoform PAD3 shows 22% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Gallus gallus Nalpha-tosyl-L-citrulline-methyl ester + NH3
-
 ?
3.5.3.15 protein L-arginine + H2O
-
 Gallus gallus protein L-citrulline + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.3.15 ? x * 73700, isoform PAD1, SDS-PAGE Gallus gallus
3.5.3.15 ? x * 74200, isoform PAD2, SDS-PAGE Gallus gallus
3.5.3.15 ? x * 74500, isoform PAD3, SDS-PAGE Gallus gallus

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD1 isoform Gallus gallus
3.5.3.15 PAD2 inactive isoform Gallus gallus
3.5.3.15 PAD3 isoform Gallus gallus
3.5.3.15 peptidylarginine deiminase
-
 Gallus gallus