Data extracted from this reference:
Application
2.1.1.1
drug development
the enzyme might be a good molecular target for lung cancer therapy
Homo sapiens
2.1.1.1
pharmacology
the enzyme might be a good molecular target for lung cancer therapy
Homo sapiens
Cloned(Commentary)
2.1.1.1
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples
Homo sapiens
Natural Substrates/ Products (Substrates)
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
?
Organism
Source Tissue
2.1.1.1
A-549 cell
Homo sapiens
2.1.1.1
additional information
quantitative real-time PCR enzyme expression analysis
Homo sapiens
2.1.1.1
non-small cell lung cancer cell
the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue
Homo sapiens
Specific Activity [micromol/min/mg]
2.1.1.1
additional information
quantitative enzyme activity analysis in 25 non-smalll cell lung cancer samples
Homo sapiens
Substrates and Products (Substrate)
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
733618
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
?
Synonyms
2.1.1.1
NNMT
Homo sapiens
Temperature Optimum [°C]
2.1.1.1
37
assay at
Homo sapiens
pH Optimum
2.1.1.1
8.6
assay at
Homo sapiens
Cofactor
2.1.1.1
S-adenosyl-L-methionine
Homo sapiens
Application (protein specific)
2.1.1.1
drug development
the enzyme might be a good molecular target for lung cancer therapy
Homo sapiens
2.1.1.1
pharmacology
the enzyme might be a good molecular target for lung cancer therapy
Homo sapiens
Cloned(Commentary) (protein specific)
2.1.1.1
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples
Homo sapiens
Cofactor (protein specific)
2.1.1.1
S-adenosyl-L-methionine
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
?
Source Tissue (protein specific)
2.1.1.1
A-549 cell
Homo sapiens
2.1.1.1
additional information
quantitative real-time PCR enzyme expression analysis
Homo sapiens
2.1.1.1
non-small cell lung cancer cell
the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue
Homo sapiens
Specific Activity [micromol/min/mg] (protein specific)
2.1.1.1
additional information
quantitative enzyme activity analysis in 25 non-smalll cell lung cancer samples
Homo sapiens
Substrates and Products (Substrate) (protein specific)
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
733618
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
?
Temperature Optimum [°C] (protein specific)
2.1.1.1
37
assay at
Homo sapiens
pH Optimum (protein specific)
2.1.1.1
8.6
assay at
Homo sapiens
General Information
2.1.1.1
malfunction
shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells
Homo sapiens
2.1.1.1
physiological function
role of nicotinamide N-methyltransferase in non-small cell lung cancer
Homo sapiens
General Information (protein specific)
2.1.1.1
malfunction
shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells
Homo sapiens
2.1.1.1
physiological function
role of nicotinamide N-methyltransferase in non-small cell lung cancer
Homo sapiens