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Literature summary extracted from

  • Albright, R.A.; Chang, W.C.; Robert, D.; Ornstein, D.L.; Cao, W.; Liu, L.; Redick, M.E.; Young, J.I.; De La Cruz, E.M.; Braddock, D.T.
    NPP4 is a procoagulant enzyme on the surface of vascular endothelium (2012), Blood, 120, 4432-4440.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.17 expression in insect cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.17 T70A active site mutant, has no effect on platelet aggregation and secretion Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.17 Homo sapiens Q9Y6X5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.17 vascular endothelium present on surface of vascular endothelium Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.17 P1,P3-bis(5'-adenosyl)triphosphate + H2O
-
 Homo sapiens AMP + ADP
-
 ?
3.6.1.17 P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
-
 Homo sapiens AMP + ATP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.17 ENPP4
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.6.1.17 physiological function the primary and secondary waves of platelet aggregation and dense granule release are strongly induced by nanomolar ENPP4 in the presence of Ap3A, while Ap3A alone initiates a primary wave of aggregation followed by rapid disaggregation. ENPP4 mediates platelet aggregation via release of ADP from Ap3A and activation of ADP receptors Homo sapiens