Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Raghav, N.; Singh, M.
    SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H (2014), Bioorg. Med. Chem., 22, 4233-4245.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 1,3,5-triphenyl pyrazole
-
Capra hircus
3.4.22.1 1,3,5-triphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 3,5-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 4-bromochalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 4-chlorochalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 4-methoxychalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 4-methylchalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 4-nitrochalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 5-(4-bromophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.1 5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-chlorophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.1 5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-methoxyphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.1 5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-methylphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.1 5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-nitrophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.1 5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 chalcone phenyl hydrazone
-
Capra hircus
3.4.22.1 N-acetyl-3,5-diphenyl pyrazolines
-
Capra hircus
3.4.22.1 N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.1 N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 1,3,5-triphenyl pyrazole
-
Capra hircus
3.4.22.16 1,3,5-triphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 3,5-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 4-bromochalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 4-chlorochalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 4-methoxychalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 4-methylchalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 4-nitrochalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 5-(4-bromophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.16 5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-chlorophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.16 5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-methoxyphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.16 5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-methylphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.16 5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-nitrophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
3.4.22.16 5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 chalcone phenyl hydrazone
-
Capra hircus
3.4.22.16 N-acetyl-3,5-diphenyl pyrazolines
-
Capra hircus
3.4.22.16 N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
3.4.22.16 N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Capra hircus H9B8T9
-
-
3.4.22.16 Capra hircus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 liver
-
Capra hircus
-
3.4.22.16 liver
-
Capra hircus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.1 0.01038
-
pH 6, 37°C Capra hircus
3.4.22.16 0.02256
-
pH 7, 37°C Capra hircus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 N-benzoyl-L-Arg-2-naphthylamide + H2O
-
Capra hircus N-benzoyl-L-Arg + 2-naphthylamine
-
?
3.4.22.16 L-Leu-2-naphthylamide + H2O
-
Capra hircus L-Leu + 2-naphthylamine
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.1 cathepsin B
-
Capra hircus
3.4.22.16 cathepsin H
-
Capra hircus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.1 37
-
assay at Capra hircus
3.4.22.16 37
-
assay at Capra hircus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.1 6
-
assay at Capra hircus
3.4.22.16 7
-
assay at Capra hircus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.1 0.000042
-
4-nitrochalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.000053
-
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.000131
-
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.001311
-
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.001311
-
5-(4-nitrophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.001365
-
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.00288
-
4-methoxychalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.00315
-
4-methylchalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.00328
-
4-chlorochalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.003883
-
4-bromochalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.0047
-
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.007243
-
5-(4-methylphenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.01
-
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.01141
-
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.01274
-
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.01274
-
chalcone phenyl hydrazone pH 6, 37°C Capra hircus
3.4.22.1 0.01481
-
5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.01767
-
N-acetyl-3,5-diphenyl pyrazolines pH 6, 37°C Capra hircus
3.4.22.1 0.0178
-
5-(4-chlorophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.038
-
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.04
-
3,5-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.0526
-
5-(4-bromophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.06711
-
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.07407
-
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.08
-
1,3,5-triphenyl pyrazole pH 6, 37°C Capra hircus
3.4.22.1 0.0909
-
1,3,5-triphenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.1087
-
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.1143
-
5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 0.149
-
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.1 1.25
-
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
3.4.22.16 0.0011
-
4-chlorochalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.001174
-
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.001568
-
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.001695
-
4-methoxychalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.001905
-
4-nitrochalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.002119
-
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.002346
-
5-(4-chlorophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.00257
-
5-(4-nitrophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.0026
-
4-bromochalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.0029
-
4-methylchalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.002907
-
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.003158
-
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.0033
-
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.0033
-
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.0038
-
5-(4-bromophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.004184
-
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.0048
-
chalcone phenyl hydrazone pH 7, 37°C Capra hircus
3.4.22.16 0.00537
-
5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.005388
-
1,3,5-triphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.006024
-
3,5-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.007396
-
5-(4-methylphenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.0082
-
5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.0098
-
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.01
-
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.01266
-
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.01767
-
N-acetyl-3,5-diphenyl pyrazolines pH 7, 37°C Capra hircus
3.4.22.16 0.01859
-
1,3,5-triphenyl pyrazole pH 7, 37°C Capra hircus
3.4.22.16 0.02432
-
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.03546
-
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
3.4.22.16 0.14
-
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus