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Literature summary extracted from

  • Tantravedi, S.; Chakraborty, S.; Shah, N.H.; Fishbein, J.C.; Hosmane, R.S.
    Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines (2013), Bioorg. Med. Chem., 21, 4893-4903.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.3 1-(4-methoxybenzyl)-4-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8-(1H)-one
-
 Oryctolagus cuniculus
3.5.4.3 1-(4-methoxybenzyl)-4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-(4-methoxybenzyl)-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-(4-methoxybenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-benzyl-5-butoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-benzyl-5-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 3-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one
-
 Oryctolagus cuniculus
3.5.4.3 5-methoxy-1-(4-methoxybenzyl)-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one
-
 Oryctolagus cuniculus
3.5.4.3 azepinomycin
-
 Oryctolagus cuniculus
3.5.4.3 iso-azepinomycin
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Oryctolagus cuniculus
-
 xanthine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.3 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 guanine + H2O
-
 Oryctolagus cuniculus xanthine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.3 guanase
-
 Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.4.3 0.0088
-
 4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.021
-
 3-benzyl-5-butoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.0265
-
 1-(4-methoxybenzyl)-4-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.0334
-
 3-(4-methoxybenzyl)-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.0397
-
 3-(4-fluorobenzyl)-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.04
-
 3-benzyl-5-hydroxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.0438
-
 1-(4-methoxybenzyl)-4-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8-(1H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.047
-
 3-benzyl-5-methoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.0475
-
 5-methoxy-1-(4-methoxybenzyl)-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(1H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 0.054
-
 3-benzyl-5-ethoxy-4,5,6,7-tetrahydroimidazo[4,5-e][1,4]diazepin-8(3H)-one at 25°C and pH 7.4 Oryctolagus cuniculus
3.5.4.3 2.5
-
 azepinomycin at 25°C and pH 7.4 Oryctolagus cuniculus