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Literature summary extracted from

  • Rashid, Y.; Kamran Azim, M.; Saify, Z.S.; Khan, K.M.; Khan, R.
    Small molecule activators of proteasome-related HslV peptidase (2012), Bioorg. Med. Chem. Lett., 22, 6089-6094.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.25.2 1-(3,4-dihydroxyphenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
 Escherichia coli
3.4.25.2 1-(3,4-dihydroxyphenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
 Haemophilus influenzae
3.4.25.2 1-(4-nitrophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
 Escherichia coli
3.4.25.2 1-(4-nitrophenyl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]ethanone
-
 Haemophilus influenzae
3.4.25.2 3-{(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-2-(4-nitrophenyl)quinazolin-4(3H)-one
-
 Escherichia coli
3.4.25.2 3-{(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-2-(4-nitrophenyl)quinazolin-4(3H)-one
-
 Haemophilus influenzae
3.4.25.2 HslU ATPase natural activator Escherichia coli
3.4.25.2 HslU ATPase natural activator Haemophilus influenzae
3.4.25.2 N'-[(E)-(4-oxo-4H-chromen-2-yl)methylidene]benzohydrazide
-
 Escherichia coli
3.4.25.2 N'-[(E)-(4-oxo-4H-chromen-2-yl)methylidene]benzohydrazide
-
 Haemophilus influenzae

Organism

EC Number Organism UniProt Comment Textmining
3.4.25.2 Escherichia coli
-
-
-
3.4.25.2 Haemophilus influenzae P43772
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.25.2 carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin + H2O the HslV peptidase alone shows a very weak peptidase activity towards carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin, but its activity increases 1-2 orders of magnitude when it binds to HslU in the presence of ATP Escherichia coli carbobenzoxy-Gly-Gly-Leu + 7-amino-4-methyl coumarin
-
 ?
3.4.25.2 carbobenzoxy-Gly-Gly-Leu-7-amido-4-methylcoumarin + H2O The HslV peptidase alone shows a very weak peptidase activity towards carbobenzoxy-Gly-Gly-Leu-7-amido-4-methyl coumarin, but its activity increases 1-2 orders of magnitude when it binds to HslU in the presence of ATP Haemophilus influenzae carbobenzoxy-Gly-Gly-Leu + 7-amino-4-methylcoumarin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.25.2 dodecamer
-
 Escherichia coli
3.4.25.2 dodecamer
-
 Haemophilus influenzae

Synonyms

EC Number Synonyms Comment Organism
3.4.25.2 HslV peptidase
-
 Escherichia coli
3.4.25.2 HslV peptidase
-
 Haemophilus influenzae

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.25.2 ATP
-
 Escherichia coli
3.4.25.2 ATP
-
 Haemophilus influenzae