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Literature summary extracted from

  • Benitez-Paez, A.; Cardenas-Brito, S.; Corredor, M.; Villarroya, M.; Armengod, M.E.
    Impairing methylations at ribosome RNA, a point mutation-dependent strategy for aminoglycoside resistance: The rsmG case (2014), Biomedica, 34, 41-49.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.170 expressed in Escherichia coli BL21(DE3) cells Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.170 G75A the mutation directly affects the S-adenosyl-L-methionine binding site, presents an almost 4fold loss of affinity and maintains the enzyme active Escherichia coli
2.1.1.170 N39A inactive Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.170 S-adenosyl-L-methionine + guanine527 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.170 Escherichia coli P0A6U5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.170 S-adenosyl-L-methionine + guanine527 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine527 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.170 rsmG
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.1.1.170 malfunction enzyme loss confers low-level streptomycin resistance and may affect ribosomal functioning Escherichia coli