EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.5 | 4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one | competitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one | uncompetitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | competitive inhibition; uncompetitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one | uncompetitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one | competitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one | noncompetitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one | competitive inhibition, enzyme-ligand interaction analysis, structure, overview | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one | uncompetitive inhibition, enzyme-ligand interaction analysis, structure, overview | Sporosarcina pasteurii | |
3.5.1.5 | 4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one | competitive inhibition | Canavalia ensiformis | |
3.5.1.5 | 4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one | competitive inhibition | Sporosarcina pasteurii | |
3.5.1.5 | Acetohydroxamic acid | time course of enzyme inhibition, overview | Canavalia ensiformis | |
3.5.1.5 | additional information | potent urease inhibitory activity of biscoumarins, mechanisms of inhibition using the nickel containing active sites of the enzyme, overview. The compounds competitively inhibit Jack bean urease through interactionwith the nickel metallocentre, as deduced from Michaelis-Menten kinetics, UV-visible absorbance spectroscopic, and molecular docking simulation studies | Canavalia ensiformis | |
3.5.1.5 | additional information | potent urease inhibitory activity of biscoumarins, mechanisms of inhibition using the nickel containing active sites of the enzyme, overview. Some of the compounds competitively inhibit Bacillus pasteurii urease through interactionwith the nickel metallocentre, as deduced from Michaelis-Menten kinetics, UV-visible absorbance spectroscopic, and molecular docking simulation studies, some comppounds behave differently. Biscoumarins bind at phenyl ring as the major active pharmacophore | Sporosarcina pasteurii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.5 | additional information | - |
additional information | steady-state kinetics analysis | Sporosarcina pasteurii | |
3.5.1.5 | additional information | - |
additional information | steady-state kinetics analysis | Canavalia ensiformis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.5 | Ni2+ | nickel metallocentre | Sporosarcina pasteurii | |
3.5.1.5 | Ni2+ | nickel metallocentre | Canavalia ensiformis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.5 | urea + H2O | Sporosarcina pasteurii | - |
CO2 + 2 NH3 | - |
? | |
3.5.1.5 | urea + H2O | Canavalia ensiformis | - |
CO2 + 2 NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.5 | Canavalia ensiformis | P07374 | - |
- |
3.5.1.5 | Sporosarcina pasteurii | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.1.5 | seed | - |
Canavalia ensiformis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.5 | urea + H2O | - |
Sporosarcina pasteurii | CO2 + 2 NH3 | - |
? | |
3.5.1.5 | urea + H2O | - |
Canavalia ensiformis | CO2 + 2 NH3 | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.1.5 | 30 | - |
assay at | Sporosarcina pasteurii |
3.5.1.5 | 30 | - |
assay at | Canavalia ensiformis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.5 | 6.8 | - |
assay at | Sporosarcina pasteurii |
3.5.1.5 | 6.8 | - |
assay at | Canavalia ensiformis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.1.5 | additional information | - |
additional information | inhibition kinetics analysis | Canavalia ensiformis | |
3.5.1.5 | additional information | - |
additional information | inhibitionkinetics analysis | Sporosarcina pasteurii | |
3.5.1.5 | 0.0133 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.015 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0155 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.019 | - |
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0193 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0215 | - |
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)-3-phenylprop-2-en-1-yl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0275 | - |
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0483 | - |
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0513 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.053 | - |
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0533 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0594 | - |
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)ethyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0595 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0629 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0636 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.0659 | - |
4-hydroxy-3-[(2E)-1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)but-2-en-1-yl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.068 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-indol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.0681 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(1H-pyrrol-3-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Sporosarcina pasteurii | |
3.5.1.5 | 0.071 | - |
4-hydroxy-3-[(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)(pyridin-4-yl)methyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis | |
3.5.1.5 | 0.075 | - |
4-hydroxy-3-[1-(4-hydroxy-2-oxo-4a,8a-dihydro-2H-chromen-3-yl)pentyl]-2H-chromen-2-one | pH 6.8, 30°C | Canavalia ensiformis |