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Literature summary extracted from

  • Sumi, D.; Himeno, S.
    Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity (2012), Biol. Pharm. Bull., 35, 1870-1875.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.137 M287T the substitution results in an increase in the capacity of the first step of methylation, leading to an increase in the percentage of urinary methylarsonate, but not the second step of methylation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.137 41700
-
 x * 41700, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite Homo sapiens
-
 S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + methylarsonite Homo sapiens
-
 S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Homo sapiens Q9HBK9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.137 A-549 cell
-
 Homo sapiens
-
2.1.1.137 HEK-293 cell
-
 Homo sapiens
-
2.1.1.137 Hep-G2 cell
-
 Homo sapiens
-
2.1.1.137 HL-60 cell
-
 Homo sapiens
-
2.1.1.137 K-562 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + methylarsonite
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.137 ? x * 41700, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
 Homo sapiens
2.1.1.137 arsenite (+3 oxidation state) methyltransferase
-
 Homo sapiens
2.1.1.137 AS3MT
-
 Homo sapiens