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Literature summary extracted from

  • Bauters, D.; Scroyen, I.; Van Hul, M.; Lijnen, H.
    Gelatinase A (MMP-2) promotes murine adipogenesis (2015), Biochim. Biophys. Acta, 1850, 1449-1456.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.24 Gelatin + H2O Mus musculus
-
 ?
-
 ?
3.4.24.24 Gelatin + H2O Mus musculus BALB/c
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.24 Mus musculus P33434 gene Mmp2
-
3.4.24.24 Mus musculus BALB/c P33434 gene Mmp2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.24 3T3-F442A cell
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 Mus musculus
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3.4.24.24 adipose tissue
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 Mus musculus
-
3.4.24.24 embryonic fibroblast
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 Mus musculus
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3.4.24.24 preadipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.24 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.24 Gelatin + H2O
-
 Mus musculus BALB/c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.24 MMP-2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.24 malfunction in de novo formed fat pads, resulting from preadipocytes with Mmp2 knockdown, the expression of aP2, Ppar-gamma and adiponectin is significantly lower, and collagen is more preserved. The fat pad weights as well as size and density of adipocytes or blood vessels are not significantly different from controls, phenotype, overview Mus musculus
3.4.24.24 metabolism expansion of adipose tissue is dependent on adipogenesis, angiogenesis and extracellular matrix remodeling by the gelatinase subfamily of the matrix metalloproteinases, overview Mus musculus
3.4.24.24 physiological function the enzyme gelatinase A is involved in adipogenesis, selective modulation of MMP-2 levels affects adipogenesis Mus musculus