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Literature summary extracted from

  • Assohou-Luty, C.; Raijmakers, R.; Benckhuijsen, W.E.; Stammen-Vogelzangs, J.; de Ru, A.; van Veelen, P.A.; Franken, K.L.; Drijfhout, J.W.; Pruijn, G.J.
    The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities (2014), Biochim. Biophys. Acta, 1844, 829-836.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.15 expressed in Escherichia coli strain BL21(DE3)pLysS, COS-1 and HEK-293 cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.3.15 Ca2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein L-arginine + H2O Homo sapiens
-
 protein L-citrulline + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Homo sapiens Q9UM07
-
-
3.5.3.15 Homo sapiens Q9Y2J8
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.15 Ni2+-NTA-agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 DDYSSSRDGYGGS + H2O substrate for isoform PAD4 Homo sapiens ?
-
 ?
3.5.3.15 DGYGGSRDSYSSS + H2O substrate for isoform PAD4 Homo sapiens ?
-
 ?
3.5.3.15 DSEGTWRKGPEAD + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 DSHKFDRDFIYSD + H2O 79% conversion by isoform PAD4 Homo sapiens DSHKFDCitDFIYSD + NH3
-
 ?
3.5.3.15 DSHKFDRDFIYSD + H2O 90% conversion by isoform PAD2 Homo sapiens DSHKFDCitDFIYSD + NH3
-
 ?
3.5.3.15 DSHKHSREWLWSD + H2O 51% conversion by isoform PAD4 Homo sapiens DSHKHSCitEWLWSD + NH3
-
 ?
3.5.3.15 DSHKHSREWLWSD + H2O 97% conversion by isoform PAD2 Homo sapiens DSHKHSCitEWLWSD + NH3
-
 ?
3.5.3.15 DSHKWHRDFFYSD + H2O 73% conversion by isoform PAD4 Homo sapiens DSHKWHCitDFFYSD + NH3
-
 ?
3.5.3.15 DSHKWHRDFFYSD + H2O 92% conversion by isoform PAD2 Homo sapiens DSHKWHCitDFFYSD + NH3
-
 ?
3.5.3.15 DSKFAFRGGIASD + H2O 25% conversion by isoform PAD4 Homo sapiens DSKFAFCitGGIASD + NH3
-
 ?
3.5.3.15 DSKFAFRGGIASD + H2O 90% conversion by isoform PAD2 Homo sapiens DSKFAFCitGGIASD + NH3
-
 ?
3.5.3.15 DSKFHFRYAVASD + H2O 92% conversion by isoform PAD2 Homo sapiens DSKFHFCitYAVASD + NH3
-
 ?
3.5.3.15 DSKFHFRYAVASD + H2O less than 20% conversion by isoform PAD4 Homo sapiens DSKFHFCitYAVASD + NH3
-
 ?
3.5.3.15 DSKFKFRYAYASD + H2O 91% conversion by isoform PAD2 Homo sapiens DSKFKFCitYAYASD + NH3
-
 ?
3.5.3.15 DSKFKFRYAYASD + H2O less than 20% conversion by isoform PAD4 Homo sapiens DSKFKFCitYAYASD + NH3
-
 ?
3.5.3.15 DSKHFHRDFIYSD + H2O 69% conversion by isoform PAD4 Homo sapiens DSKHFHCitDFIYSD + NH3
-
 ?
3.5.3.15 DSKHFHRDFIYSD + H2O 94% conversion by isoform PAD2 Homo sapiens DSKHFHCitDFIYSD + NH3
-
 ?
3.5.3.15 DSKHKSRDFVYSD + H2O 69% conversion by isoform PAD4 Homo sapiens DSKHKSCitDFVYSD + NH3
-
 ?
3.5.3.15 DSKHKSRDFVYSD + H2O 94% conversion by isoform PAD2 Homo sapiens DSKHKSCitDFVYSD + NH3
-
 ?
3.5.3.15 DSKHLSREWMWSD + H2O 54% conversion by isoform PAD4 Homo sapiens DSKHLSCitEWMWSD + NH3
-
 ?
3.5.3.15 DSKHLSREWMWSD + H2O 95% conversion by isoform PAD2 Homo sapiens DSKHLSCitEWMWSD + NH3
-
 ?
3.5.3.15 DSKKFDRDHLYSD + H2O 77% conversion by isoform PAD4 Homo sapiens DSKKFDCitDHLYSD + NH3
-
 ?
3.5.3.15 DSKKFDRDHLYSD + H2O 90% conversion by isoform PAD2 Homo sapiens DSKKFDCitDHLYSD + NH3
-
 ?
3.5.3.15 DSKKFDRGHLYSD + H2O 80% conversion by isoform PAD4 Homo sapiens DSKKFDCitGHLYSD + NH3
-
 ?
3.5.3.15 DSKKFDRGHLYSD + H2O 90% conversion by isoform PAD2 Homo sapiens DSKKFDCitGHLYSD + NH3
-
 ?
3.5.3.15 DSKKFHRDFLYSD + H2O 64% conversion by isoform PAD4 Homo sapiens DSKKFHCitDFLYSD + NH3
-
 ?
3.5.3.15 DSKKFHRDFLYSD + H2O 97% conversion by isoform PAD2 Homo sapiens DSKKFHCitDFLYSD + NH3
-
 ?
3.5.3.15 DSKKFHRGFLYSD + H2O 100% conversion by isoform PAD2 Homo sapiens DSKKFHCitGFLYSD + NH3
-
 ?
3.5.3.15 DSKKFHRGFLYSD + H2O 73% conversion by isoform PAD4 Homo sapiens DSKKFHCitGFLYSD + NH3
-
 ?
3.5.3.15 DSKKFKRDFLFSD + H2O 35% conversion by isoform PAD4 Homo sapiens DSKKFKCitDFLFSD + NH3
-
 ?
3.5.3.15 DSKKFKRDFLFSD + H2O 97% conversion by isoform PAD2 Homo sapiens DSKKFKCitDFLFSD + NH3
-
 ?
3.5.3.15 DSKKHDRDHLWSD + H2O 80% conversion by isoform PAD4 Homo sapiens DSKKHDCitDHLWSD + NH3
-
 ?
3.5.3.15 DSKKHDRDHLWSD + H2O 95% conversion by isoform PAD2 Homo sapiens DSKKHDCitDHLWSD + NH3
-
 ?
3.5.3.15 DSKKHFRDKLYSD + H2O 37% conversion by isoform PAD4 Homo sapiens DSKKHFCitDKLYSD + NH3
-
 ?
3.5.3.15 DSKKHFRDKLYSD + H2O 92% conversion by isoform PAD2 Homo sapiens DSKKHFCitDKLYSD + NH3
-
 ?
3.5.3.15 DSKKHFRGKLYSD + H2O 22% conversion by isoform PAD4 Homo sapiens DSKKHFCitGKLYSD + NH3
-
 ?
3.5.3.15 DSKKHFRGKLYSD + H2O 96% conversion by isoform PAD2 Homo sapiens DSKKHFCitGKLYSD + NH3
-
 ?
3.5.3.15 DSKKKHREWVWSD + H2O 100% conversion by isoform PAD2 Homo sapiens DSKKKHCitEWVWSD + NH3
-
 ?
3.5.3.15 DSKKKHREWVWSD + H2O 72% conversion by isoform PAD4 Homo sapiens DSKKKHCitEWVWSD + NH3
-
 ?
3.5.3.15 DSKKLHRDHMESD + H2O 65% conversion by isoform PAD4 Homo sapiens DSKKLHCitDHMESD + NH3
-
 ?
3.5.3.15 DSKKLHRDHMESD + H2O 90% conversion by isoform PAD2 Homo sapiens DSKKLHCitDHMESD + NH3
-
 ?
3.5.3.15 DSKKYDRDFLWSD + H2O 76% conversion by isoform PAD4 Homo sapiens DSKKYDCitDFLWSD + NH3
-
 ?
3.5.3.15 DSKKYDRDFLWSD + H2O 92% conversion by isoform PAD2 Homo sapiens DSKKYDCitDFLWSD + NH3
-
 ?
3.5.3.15 DSKKYDRGFLWSD + H2O 81% conversion by isoform PAD4 Homo sapiens DSKKYDCitGFLWSD + NH3
-
 ?
3.5.3.15 DSKKYDRGFLWSD + H2O 93% conversion by isoform PAD2 Homo sapiens DSKKYDCitGFLWSD + NH3
-
 ?
3.5.3.15 DSKWHHRDHLYSD + H2O 71% conversion by isoform PAD4 Homo sapiens DSKWHHCitDHLYSD + NH3
-
 ?
3.5.3.15 DSKWHHRDHLYSD + H2O 90% conversion by isoform PAD2 Homo sapiens DSKWHHCitDHLYSD + NH3
-
 ?
3.5.3.15 DSKWHHRGHLYSD + H2O 71% conversion by isoform PAD4 Homo sapiens DSKWHHCitGHLYSD + NH3
-
 ?
3.5.3.15 DSKWHHRGHLYSD + H2O 96% conversion by isoform PAD2 Homo sapiens DSKWHHCitGHLYSD + NH3
-
 ?
3.5.3.15 DSKWYHRNKFWSD + H2O 45% conversion by isoform PAD4 Homo sapiens DSKWYHCitNKFWSD + NH3
-
 ?
3.5.3.15 DSKWYHRNKFWSD + H2O 98% conversion by isoform PAD2 Homo sapiens DSKWYHCitNKFWSD + NH3
-
 ?
3.5.3.15 DSQFAFRGASASD + H2O less than 20% conversion by isoform PAD2 Homo sapiens DSQFAFCitGASASD + NH3
-
 ?
3.5.3.15 DSQFAFRGASASD + H2O less than 20% conversion by isoform PAD4 Homo sapiens DSQFAFCitGASASD + NH3
-
 ?
3.5.3.15 DSQWAFRHALFSD + H2O 95% conversion by isoform PAD2 Homo sapiens DSQWAFCitHALFSD + NH3
-
 ?
3.5.3.15 DSQWAFRHALFSD + H2O less than 20% conversion by isoform PAD4 Homo sapiens DSQWAFCitHALFSD + NH3
-
 ?
3.5.3.15 DSRFYWRGGGKSD + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 DSSEELRGGGKSD + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 DSYRSWRDGYYSD + H2O substrate for isoform PAD4 Homo sapiens ?
-
 ?
3.5.3.15 FFDSHKFDRDFIYSD + H2O 94% conversion by isoform PAD4 Homo sapiens FFDSHKFDCitDFIYSD + NH3
-
 ?
3.5.3.15 FFDSHKFDRDFIYSD + H2O 97% conversion by isoform PAD2 Homo sapiens FFDSHKFDCitDFIYSD + NH3
-
 ?
3.5.3.15 FFDSHKHSREWLWSD + H2O 22% conversion by isoform PAD4 Homo sapiens FFDSHKHSCitEWLWSD + NH3
-
 ?
3.5.3.15 FFDSHKHSREWLWSD + H2O 96% conversion by isoform PAD2 Homo sapiens FFDSHKHSCitEWLWSD + NH3
-
 ?
3.5.3.15 FFDSHKKSREYVFSD + H2O 100% conversion by isoform PAD2 Homo sapiens FFDSHKKSCitEYVFSD + NH3
-
 ?
3.5.3.15 FFDSHKKSREYVFSD + H2O 58% conversion by isoform PAD4 Homo sapiens FFDSHKKSCitEYVFSD + NH3
-
 ?
3.5.3.15 FFDSHKLHREWMWSD + H2O 91% conversion by isoform PAD4 Homo sapiens FFDSHKLHCitEWMWSD + NH3
-
 ?
3.5.3.15 FFDSHKLHREWMWSD + H2O 92% conversion by isoform PAD2 Homo sapiens FFDSHKLHCitEWMWSD + NH3
-
 ?
3.5.3.15 FFDSHKWHRDFFYSD + H2O 88% conversion by isoform PAD4 Homo sapiens FFDSHKWHCitDFFYSD + NH3
-
 ?
3.5.3.15 FFDSHKWHRDFFYSD + H2O 9% conversion by isoform PAD2 Homo sapiens FFDSHKWHCitDFFYSD + NH3
-
 ?
3.5.3.15 FFDSKHFDREWIWSD + H2O 89% conversion by isoform PAD4 Homo sapiens FFDSKHFDCitEWIWSD + NH3
-
 ?
3.5.3.15 FFDSKHFDREWIWSD + H2O 94% conversion by isoform PAD2 Homo sapiens FFDSKHFDCitEWIWSD + NH3
-
 ?
3.5.3.15 FFDSKHKSRDFVYSD + H2O 77% conversion by isoform PAD4 Homo sapiens FFDSKHKSCitDFVYSD + NH3
-
 ?
3.5.3.15 FFDSKHKSRDFVYSD + H2O 92% conversion by isoform PAD2 Homo sapiens FFDSKHKSCitDFVYSD + NH3
-
 ?
3.5.3.15 FFDSKHLSREWMWSD + H2O 73% conversion by isoform PAD4 Homo sapiens FFDSKHLSCitEWMWSD + NH3
-
 ?
3.5.3.15 FFDSKHLSREWMWSD + H2O 97% conversion by isoform PAD2 Homo sapiens FFDSKHLSCitEWMWSD + NH3
-
 ?
3.5.3.15 FFDSKKFSRDHIESD + H2O 63% conversion by isoform PAD4 Homo sapiens FFDSKKFSCitDHIESD + NH3
-
 ?
3.5.3.15 FFDSKKFSRDHIESD + H2O 90% conversion by isoform PAD2 Homo sapiens FFDSKKFSCitDHIESD + NH3
-
 ?
3.5.3.15 FFDSKKKHREWVWSD + H2O 76% conversion by isoform PAD4 Homo sapiens FFDSKKKHCitEWVWSD + NH3
-
 ?
3.5.3.15 FFDSKKKHREWVWSD + H2O 99% conversion by isoform PAD2 Homo sapiens FFDSKKKHCitEWVWSD + NH3
-
 ?
3.5.3.15 FFDSKKWSREYFFSD + H2O 76% conversion by isoform PAD4 Homo sapiens FFDSKKWSCitEYFFSD + NH3
-
 ?
3.5.3.15 FFDSKKWSREYFFSD + H2O 94% conversion by isoform PAD2 Homo sapiens FFDSKKWSCitEYFFSD + NH3
-
 ?
3.5.3.15 GYGGGSRDGSYGG + H2O substrate for isoform PAD4 Homo sapiens ?
-
 ?
3.5.3.15 IEIITDRQSGKKR + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 IEIMTDRGSGKKR + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 IGSRGDRSGFGKF + H2O substrate for isoform PAD2 Homo sapiens ?
-
 ?
3.5.3.15 protein L-arginine + H2O
-
 Homo sapiens protein L-citrulline + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD2 isoform Homo sapiens
3.5.3.15 PAD4 isoform Homo sapiens
3.5.3.15 peptidylarginine deiminase
-
 Homo sapiens