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Literature summary extracted from

  • Boncoeur, E.; Durmort, C.; Bernay, B.; Ebel, C.; Di Guilmi, A.M.; Croize, J.; Vernet, T.; Jault, J.M.
    PatA and PatB form a functional heterodimeric ABC multidrug efflux transporter responsible for the resistance of Streptococcus pneumoniae to fluoroquinolones (2012), Biochemistry, 51, 7755-7765.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 expressed in Escherichia coli Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 orthovanadate
-
 Streptococcus pneumoniae
7.6.2.2 reserpine
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + ethidium bromide/in
-
 Streptococcus pneumoniae ADP + phosphate + ethidium bromide/out
-
 ?
7.6.2.2 ATP + H2O + fluoroquinolone/in
-
 Streptococcus pneumoniae ADP + phosphate + fluoroquinolone/out
-
 ?
7.6.2.2 ATP + H2O + Hoechst 33342/in
-
 Streptococcus pneumoniae ADP + phosphate + Hoechst 33342/out
-
 ?

Subunits

EC Number Subunits Comment Organism
7.6.2.2 heterodimer subunits PatA and PatB need to interact together to make a functional drug efflux transporter and work only as heterodimers Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 PatA/PatB
-
 Streptococcus pneumoniae