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Literature summary extracted from

  • Kurogi, K.; Alazizi, A.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Sugahara, T.; Liu, M.C.
    Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs (2012), Biochem. Pharmacol., 84, 1186-1195.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 dopamine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 epinephrine + S-adenosyl-L-methionine
-
 Homo sapiens metanephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.6 isoetharine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 isoproterenol + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?

General Information

EC Number General Information Comment Organism
2.1.1.6 physiological function inhibition of catechol O-methyltransferase by inhibitor tropolone results in a decrease of the total amount of sulfated metabolites of dopamine, epinephrine, isoproterenol, and isoetharine. The sequential methylation and sulfation of dopamine, epinephrine, isoproterenol, and isoetharine is mediated by, respectively, the COMT and the cytosolic sulfotransferase SULT1A3 Homo sapiens