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Literature summary extracted from

  • Tatham, M.H.; Plechanovova, A.; Jaffray, E.G.; Salmen, H.; Hay, R.T.
    Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini (2013), Biochem. J., 453, 137-145.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.25 Homo sapiens Q96B02
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.25 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [SUMO-2]-N-terminal-amino acid
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 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[SUMO-2] N-terminal mono-ubiquitylation of SUMO-2 primes it for poly-ubiquitylation by the Ubc13-UEV1 (ubiquitin-conjugating enzyme E2 variant 1) heterodimer ?
2.3.2.25 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [Ube2W]-N-terminal-amino acid
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 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[Ube2W] isoform Ube2W ubiquitylates its own N-terminus ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.25 Ubc16
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 Homo sapiens
2.3.2.25 UBE2W
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 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.25 physiological function Ube2W is an E2 ubiquitin-conjugating enzyme with specific protein N-terminal monoubiquitylation activity. Ube2W conjugates ubiquitin to its own N-terminus, but also to that of the small ubiquitin-like modifier SUMO in a manner dependent on the SUMO-targeted ubiquitin ligase RNF4, i.e.RING finger protein 4 Homo sapiens