EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.1 | recombinant stable expression of NNMT-V5 in SH-SY5Y cells increases complex I activity via sirtuin 3 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine + nicotinamide | Homo sapiens | - |
S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.1 | brain | the enzyme is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis | Homo sapiens | - |
2.1.1.1 | additional information | SH-SY5Y human neuroblastoma cells have no endogenous expression of enzyme NNMT | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine + nicotinamide | - |
Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.1 | NNMT | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.1 | S-adenosyl-L-methionine | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.1 | additional information | in vitro overexpression of the enzyme has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. siRNA-mediated silencing of sirtuin 3 expression decreases complex I activity in NNMT-expressing SH-SY5Y cells to that observed in wild-type SH-SY5Y, and significantly reduces cellular ATP content also | Homo sapiens |
2.1.1.1 | physiological function | expression of enzyme NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells significantly increases the expression of all three sirtuins, class III DNA deacetylase enzymes known to regulate mitochondrial energy production and cell cycle. Sirtuin 3 is a key mediator of NNMT-induced complex I activity and ATP synthesis. Central role for enzyme NNMT in the regulation of energy homeostasis | Homo sapiens |