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Literature summary extracted from

  • Nakajima, K.; Niisato, N.; Marunaka, Y.
    Enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase (2012), Biochem. Biophys. Res. Commun., 425, 225-229.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.6 Br-
-
 Sus scrofa
3.6.5.6 Cl- enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase. GTPase activity of tubulin is lower (2/3-fold) in Cl--containing solutions than that in Cl--free solutions containing Br- or NO3- Sus scrofa
3.6.5.6 NO3-
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.5.6 microtubule
-
 Sus scrofa 5874
-
3.6.5.6 neurite
-
 Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.5.6 Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.6 GTP + H2O Sus scrofa
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.6 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.6 brain
-
 Sus scrofa
-
3.6.5.6 neuron
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.6 GTP + H2O
-
 Sus scrofa GDP + phosphate
-
 ?
3.6.5.6 additional information efficiency of in vitro tubulin polymerization in solutions containing a non-hydrolyzable analogue of GTP, GpCpp, instead of GTP is much higher than that in the presence of GTP Sus scrofa ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.5.6 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.5.6 7.4
-
 assay at Sus scrofa

General Information

EC Number General Information Comment Organism
3.6.5.6 malfunction enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase Sus scrofa
3.6.5.6 physiological function a part of stimulatory effects of Cl- on in vitro tubulin polymerization is mediated via an inhibitory effect on GTPase activity of tubulin, although Cl- also regulates in vitro tubulin polymerization by factors other than an inhibitory effect on GTPase activity Sus scrofa