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Literature summary extracted from

  • Giner, J.L.; Djerassi, C.
    Inhibition and substrate specificity of yeast DELTA22-desaturase (1990), Biochem. Biophys. Res. Commun., 173, 60-66.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.41 (20S)-21-isocyano-20-methylpregn-5-en-3beta-ol complete inhibition at 0.15 mM Saccharomyces cerevisiae
1.14.19.41 additional information not inhibited by desmosterol, 24-methylenecholesterol, and 24-bromocholesterol Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.41 microsome
-
 Saccharomyces cerevisiae
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.41 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.41 22,23-dihydrobrassicasterol + NADPH + H+ + O2 highest activity Saccharomyces cerevisiae brassicasterol + NADP+ + H2O
-
 ?
1.14.19.41 clionasterol + NADPH + H+ + O2
-
 Saccharomyces cerevisiae poriferasterol + NADP+ + H2O
-
 ?
1.14.19.41 sitosterol + NADPH + H+ + O2
-
 Saccharomyces cerevisiae stigmasterol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.41 DELTA22-desaturase
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.41 NADPH
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.41 0.015
-
 at 27°C, pH not specified in the publication Saccharomyces cerevisiae (20S)-21-isocyano-20-methylpregn-5-en-3beta-ol