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Literature summary extracted from

  • Useglio, M.; Peiru, S.; Rodriguez, E.; Labadie, G.R.; Carney, J.R.; Gramajo, H.
    TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli (2010), Appl. Environ. Microbiol., 76, 3869-3877.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.159 expression in Escherichia coli Micromonospora megalomicea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose Micromonospora megalomicea
-
 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O enzyme MegBVI is involved in the C-2 deoxygenation step during the biosynthesis of TDP-L-mycarose, generating the intermediate TDP-2,6-dideoxy-3,4-dioxo-D-glucose ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.159 Micromonospora megalomicea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose
-
 Micromonospora megalomicea dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O enzyme MegBVI is involved in the C-2 deoxygenation step during the biosynthesis of TDP-L-mycarose, generating the intermediate TDP-2,6-dideoxy-3,4-dioxo-D-glucose ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.159 megBVI
-
 Micromonospora megalomicea

General Information

EC Number General Information Comment Organism
4.2.1.159 physiological function production of TDP-L-megosamine from TDP-4-keto-6-deoxy-D-glucose requires only five biosynthetic steps, catalyzed by MegBVI, MegDII, MegDIII, MegDIV, and MegDV Micromonospora megalomicea