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Literature summary extracted from

  • Sokmen, B.B.; Hasdemir, B.; Yusufoglu, A.; Yanardag, R.
    Some monohydroxy tetradecanoic acid isomers as novel urease and elastase inhibitors and as new antioxidants (2014), Appl. Biochem. Biotechnol., 172, 1358-1364.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.5 drug development 3-,6-,7-,9-,12-monohydroxy tetradecanoic acid isomers can be used in agriculture, pharmacy and cosmetic industries due to their excellent antielastase, antiurease and antioxidant activities. Hydroxy fatty acids can be urease inhibitors and anti-Helicobacter pylori agents due to their antiurease activity Helicobacter pylori

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 12-hydroxytetradecanoic acid 48.47% inhibition at 100 ng/ml Helicobacter pylori
3.5.1.5 3-hydroxytetradecanoic acid 49.20% inhibition at 100 ng/ml Helicobacter pylori
3.5.1.5 6-hydroxytetradecanoic acid 59.01% inhibition at 100 ng/ml Helicobacter pylori
3.5.1.5 7-hydroxytetradecanoic acid 53.43% inhibition at 100 ng/ml Helicobacter pylori
3.5.1.5 9-hydroxytetradecanoic acid 52.97% inhibition at 100 ng/ml Helicobacter pylori
3.5.1.5 additional information evaluation of 3-,6-,7-,9-,12-monohydroxy tetradecanoic acids as enzyme inhibitors in agriculture, overview Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.5 urea + H2O Helicobacter pylori
-
 CO2 + 2 NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Helicobacter pylori CO2 + 2 NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.5 urea amido hydrolase
-
 Helicobacter pylori

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 0.07
-
 pH and temperature not specified in the publication Helicobacter pylori 6-hydroxytetradecanoic acid
3.5.1.5 0.083
-
 pH and temperature not specified in the publication Helicobacter pylori 9-hydroxytetradecanoic acid
3.5.1.5 0.09
-
 pH and temperature not specified in the publication Helicobacter pylori 7-hydroxytetradecanoic acid
3.5.1.5 0.1
-
 pH and temperature not specified in the publication Helicobacter pylori 3-hydroxytetradecanoic acid
3.5.1.5 0.101
-
 pH and temperature not specified in the publication Helicobacter pylori 12-hydroxytetradecanoic acid