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Literature summary extracted from

  • Takaya, A.; Sato, Y.; Shoji, T.; Yamamoto, T.
    Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible (2013), Antimicrob. Agents Chemother., 57, 3789-3796.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.188 A135T inactive Streptococcus pneumoniae
2.1.1.188 C23R inactive Streptococcus pneumoniae
2.1.1.188 C36R inactive Streptococcus pneumoniae
2.1.1.188 L113P inactive Streptococcus pneumoniae
2.1.1.188 L164P inactive Streptococcus pneumoniae
2.1.1.188 L165P inactive Streptococcus pneumoniae
2.1.1.188 L247P inactive Streptococcus pneumoniae
2.1.1.188 R200C inactive Streptococcus pneumoniae
2.1.1.188 Y212C inactive Streptococcus pneumoniae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.188 31500
-
 x * 31500, calculated from amino acid sequence Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptococcus pneumoniae
-
 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA Streptococcus pneumoniae S1
-
 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.188 Streptococcus pneumoniae
-
-
-
2.1.1.188 Streptococcus pneumoniae S1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA
-
 Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?
2.1.1.188 S-adenosyl-L-methionine + guanine748 in 23S rRNA
-
 Streptococcus pneumoniae S1 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.188 ? x * 31500, calculated from amino acid sequence Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
2.1.1.188 RlmAII
-
 Streptococcus pneumoniae
2.1.1.188 TlrB
-
 Streptococcus pneumoniae

General Information

EC Number General Information Comment Organism
2.1.1.188 malfunction the inactivation of the enzyme confers telithromycin resistance Streptococcus pneumoniae
2.1.1.188 physiological function methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible Streptococcus pneumoniae