EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.16 | 2-(acetylamino)-6-aminoheptanedioic acid | - |
Escherichia coli | |
3.5.1.16 | 2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid | slight inhibition | Escherichia coli | |
3.5.1.16 | 2-amino-6-[(4-carboxy-3-methylbutanoyl)amino]heptanedioic acid | slight inhibition | Escherichia coli | |
3.5.1.16 | 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid | - |
Escherichia coli | |
3.5.1.16 | 2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid | slight inhibition | Escherichia coli | |
3.5.1.16 | additional information | mono-N-acyl derivatives of 2,6-diaminopimelic acid as enzyme inhibitors, overview. No inhibition by 2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid, 2-amino-6-(butanoylamino)heptanedioic acid, 2-amino-6-[(2,2-dimethylpropanoyl)amino]heptanedioic acid, 2-amino-6-(pentanoylamino)heptanedioic acid, 2-amino-6-(benzoylamino)heptanedioic acid, 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-2,2,3,3-tetrafluorobutanoyl)amino]heptanedioic acid, 2-amino-6-[(3-ethoxy-3-oxopropanoyl)amino]heptanedioic acid, and 2-amino-6-[[(2R)-4-methoxy-2-methylpent-4-enoyl]amino]heptanedioic acid | Escherichia coli | |
3.5.1.18 | 2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid | slight inhibition | Haemophilus influenzae | |
3.5.1.18 | additional information | mono-N-acyl derivatives of 2,6-diaminopimelic acid are no effective N-succinyl-L,L-diaminopimelic acid desuccinylase inhibitors, overview. No inhibition by 2-amino-6-(butanoylamino)heptanedioic acid, 2-amino-6-[(2,2-dimethylpropanoyl)amino]heptanedioic acid, 2-amino-6-(pentanoylamino)heptanedioic acid, 2-amino-6-(benzoylamino)heptanedioic acid, 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-3-methylbutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid, 2-amino-6-[(4-carboxy-2,2,3,3-tetrafluorobutanoyl)amino]heptanedioic acid, 2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid, 2-amino-6-[(3-ethoxy-3-oxopropanoyl)amino]heptanedioic acid, and 2-amino-6-[[(2R)-4-methoxy-2-methylpent-4-enoyl]amino]heptanedioic acid | Haemophilus influenzae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.16 | N2-acetyl-L-ornithine + H2O | Escherichia coli | - |
acetate + L-ornithine | - |
? | |
3.5.1.18 | N-succinyl-LL-2,6-diaminoheptanedioate + H2O | Haemophilus influenzae | - |
succinate + LL-2,6-diaminoheptanedioate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.16 | Escherichia coli | - |
gene argE | - |
3.5.1.18 | Haemophilus influenzae | - |
gene dapE | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.16 | N2-acetyl-L-ornithine + H2O | - |
Escherichia coli | acetate + L-ornithine | - |
? | |
3.5.1.18 | N-succinyl-LL-2,6-diaminoheptanedioate + H2O | - |
Haemophilus influenzae | succinate + LL-2,6-diaminoheptanedioate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.1.16 | ArgE | - |
Escherichia coli |
3.5.1.18 | DapE | - |
Haemophilus influenzae |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.5.1.16 | 25 | - |
assay at | Escherichia coli |
3.5.1.18 | 25 | - |
assay at | Haemophilus influenzae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.1.16 | 7.5 | - |
assay at | Escherichia coli |
3.5.1.18 | 7.5 | - |
assay at | Haemophilus influenzae |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.5.1.16 | 0.48 | - |
pH 7.5, 25°C | Escherichia coli | 2-(acetylamino)-6-aminoheptanedioic acid | |
3.5.1.16 | 1.28 | - |
pH 7.5, 25°C | Escherichia coli | 2-amino-6-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]heptanedioic acid | |
3.5.1.16 | 2.11 | - |
pH 7.5, 25°C | Escherichia coli | 2-amino-6-[(4-carboxy-3,3-dimethylbutanoyl)amino]heptanedioic acid | |
3.5.1.16 | 2.63 | - |
pH 7.5, 25°C | Escherichia coli | 2-amino-6-[(4-carboxybutanoyl)amino]heptanedioic acid | |
3.5.1.18 | 17 | - |
pH 7.5, 25°C | Haemophilus influenzae | 2-amino-6-[(2-methylpropanoyl)amino]heptanedioic acid |