EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.11 | thiorphan | - |
Homo sapiens | |
3.4.24.11 | U46619 | a thromboxane mimetic | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.11 | extracellular | located on the lung surface | Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | pulmonary vasodilative vasoactive intestinal peptide + H2O | Homo sapiens | rapid inactivation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.11 | Homo sapiens | P08473 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.11 | lung | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | pulmonary vasodilative vasoactive intestinal peptide + H2O | rapid inactivation | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.11 | NEP | - |
Homo sapiens |
3.4.24.11 | neutral endopeptidase | - |
Homo sapiens |
3.4.24.11 | neutral endopeptidase 24.11 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.24.11 | malfunction | enzyme inhibition augmentes the maximum hemodynamic effects of pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, aerosol, and also leads to a significant prolongation of these effects | Homo sapiens |
3.4.24.11 | physiological function | the enzyme inhibits the pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, in lungs of subjects with pathophysiology of pulmonary hypertension (due to a deficiency in VIP) by rapid inactivation of VIP | Homo sapiens |