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Literature summary extracted from

  • Leuchte, H.H.; Prechtl, C.; Callegari, J.; Meis, T.; Haziraj, S.; Bevec, D.; Behr, J.
    Augmentation of the effects of vasoactive intestinal peptide aerosol on pulmonary hypertension via coapplication of a neutral endopeptidase 24.11 inhibitor (2015), Am. J. Physiol. Lung Cell Mol. Physiol., 308, L563-L568.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 thiorphan
-
Homo sapiens
3.4.24.11 U46619 a thromboxane mimetic Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.11 extracellular located on the lung surface Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.11 pulmonary vasodilative vasoactive intestinal peptide + H2O Homo sapiens rapid inactivation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Homo sapiens P08473
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 lung
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 pulmonary vasodilative vasoactive intestinal peptide + H2O rapid inactivation Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.11 NEP
-
Homo sapiens
3.4.24.11 neutral endopeptidase
-
Homo sapiens
3.4.24.11 neutral endopeptidase 24.11
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.11 malfunction enzyme inhibition augmentes the maximum hemodynamic effects of pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, aerosol, and also leads to a significant prolongation of these effects Homo sapiens
3.4.24.11 physiological function the enzyme inhibits the pulmonary vasodilation by pulmonary vasodilative vasoactive intestinal peptide, VIP, in lungs of subjects with pathophysiology of pulmonary hypertension (due to a deficiency in VIP) by rapid inactivation of VIP Homo sapiens