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Literature summary extracted from

  • Knapik-Czajka, M.
    Simvastatin increases liver branched-chain alpha-ketoacid dehydrogenase activity in rats fed with low protein diet (2014), Toxicology, 325, 107-114.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.4.4 simvastatin
-
 Rattus norvegicus
3.1.3.52 simvastatin
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.4 Rattus norvegicus
-
-
-
3.1.3.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.4 liver
-
 Rattus norvegicus
-
3.1.3.52 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.4 2-oxoisovalerate + NAD+
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.4 BCKDH
-
 Rattus norvegicus
1.2.4.4 branched-chain alpha-ketoacid dehydrogenase
-
 Rattus norvegicus
3.1.3.52 alpha-ketoacid dehydrogenase
-
 Rattus norvegicus
3.1.3.52 BCKDH
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.1.3.52 malfunction Simvastatin administration increases BCKDH activity state and stimulates branched-chain amino acids (BCAAs) catabolism in rats fed with the low protein diet In contrast to rats subjected to protein restriction simvastatin has no effect on liver BCKDH activity in rats fed with the standard diet Rattus norvegicus