EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.2.4.4 | simvastatin | - |
Rattus norvegicus | |
3.1.3.52 | simvastatin | - |
Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.4.4 | Rattus norvegicus | - |
- |
- |
3.1.3.52 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.2.4.4 | liver | - |
Rattus norvegicus | - |
3.1.3.52 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.4.4 | 2-oxoisovalerate + NAD+ | - |
Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.4.4 | BCKDH | - |
Rattus norvegicus |
1.2.4.4 | branched-chain alpha-ketoacid dehydrogenase | - |
Rattus norvegicus |
3.1.3.52 | alpha-ketoacid dehydrogenase | - |
Rattus norvegicus |
3.1.3.52 | BCKDH | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.52 | malfunction | Simvastatin administration increases BCKDH activity state and stimulates branched-chain amino acids (BCAAs) catabolism in rats fed with the low protein diet In contrast to rats subjected to protein restriction simvastatin has no effect on liver BCKDH activity in rats fed with the standard diet | Rattus norvegicus |