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Literature summary extracted from

  • Yousif, A.S.; Stanlie, A.; Mondal, S.; Honjo, T.; Begum, N.A.
    Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase (2014), Proc. Natl. Acad. Sci. USA, 111, E1016-E1024.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.2.2.27 DELTA90 the mutant shows about 180 of wild type uracil removal activity Mus musculus
3.2.2.27 DELTA90/W231A the mutant less than 20% of wild type uracil removal activity Mus musculus
3.2.2.27 W231A the mutant shows about 20% of wild type uracil removal activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O Mus musculus
-
 uracil + DNA with abasic site
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.27 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.27 B-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O
-
 Mus musculus uracil + DNA with abasic site
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.27 UNG
-
 Mus musculus
3.2.2.27 uracil DNA glycosylase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.2.2.27 malfunction enzyme deficiency enhances translesion polymerase recruitment and inhibits S-S synapse formation during class switch recombination Mus musculus
3.2.2.27 physiological function the noncanonical function of the enzyme regulates the steps after activation-induced cytidine deaminase-induced DNA cleavage: errorprone repair suppression in S region somatic hypermutation and end-joining promotion in class switch recombination Mus musculus