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Literature summary extracted from

  • Stsiapanava, A.; Olsson, U.; Wan, M.; Kleinschmidt, T.; Rutishauser, D.; Zubarev, R.A.; Samuelsson, B.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
    Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor (2014), Proc. Natl. Acad. Sci. USA, 111, 4227-4232.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.6 expressed in Escherichia coli JM101 cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.3.2.6 mutant E296Q in complex with N-(4-oxo-4-pyrrolidinyl-butanoyl)-L-proline, liquid/liquid diffusion method, using 22-30% (w/v) PEG 8000, 100 mM NaAc, 100 mM imidazole buffer (pH 6.5-7.0), and 5 mM YbCl3 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.6 E296Q inactive Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 4-(4-benzylphenyl)thiazol-2-amine
-
 Homo sapiens
3.3.2.6 SC-57461A i.e. N-[3-(4-benzylphenoxy)propyl]-N-methyl-beta-L-alanine Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zn2+ zinc metalloenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens P09960
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.6
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 L-Ala-4-nitroanilide + H2O
-
 Homo sapiens L-Ala + 4-nitroaniline
-
 ?
3.3.2.6 L-Pro-Gly-L-Pro + H2O
-
 Homo sapiens ?
-
 ?
3.3.2.6 L-Val-4-nitroanilide + H2O
-
 Homo sapiens L-Val + 4-nitroaniline
-
 ?
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
 Homo sapiens
3.3.2.6 leukotriene A4 hydrolase/aminopeptidase
-
 Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.3.2.6 0.0023
-
 4-(4-benzylphenyl)thiazol-2-amine at pH 7.8 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.0005
-
 at pH 7.8 and 37°C Homo sapiens 4-(4-benzylphenyl)thiazol-2-amine