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Literature summary extracted from

  • Marques, J.C.; Oh, I.K.; Ly, D.C.; Lamosa, P.; Ventura, M.R.; Miller, S.T.; Xavier, K.B.
    LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2 (2014), Proc. Natl. Acad. Sci. USA, 111, 14235-14240.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.245 crystals of the catalytically inactive mutant enzyme K203A Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.245 K203A inactive mutant enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.245 3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A Escherichia coli the enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2 i.e. (S)-4,5-dihydroxypentane-2,3-dione glycerone phosphate + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.245 Escherichia coli P76143
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.245 3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A
-
 Escherichia coli glycerone phosphate + acetyl-CoA
-
 ?
2.3.1.245 3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A the enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2 i.e. (S)-4,5-dihydroxypentane-2,3-dione Escherichia coli glycerone phosphate + acetyl-CoA
-
 ?

General Information

EC Number General Information Comment Organism
2.3.1.245 metabolism the enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2 Escherichia coli