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Literature summary extracted from

  • Feng, L.; Liu, X.; Zhu, W.; Guo, F.; Wu, Y.; Wang, R.; Chen, K.; Huang, C.; Li, Y.
    Inhibition of human neutrophil elastase by pentacyclic triterpenes (2013), PLoS ONE, 8, e82794.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 astragaloside IV
-
Homo sapiens
3.4.21.37 betulinic acid
-
Homo sapiens
3.4.21.37 cucurbitacin B
-
Homo sapiens
3.4.21.37 ginsenoside Re
-
Homo sapiens
3.4.21.37 glycyrrhetinic acid
-
Homo sapiens
3.4.21.37 glycyrrhizin
-
Homo sapiens
3.4.21.37 lupeol
-
Homo sapiens
3.4.21.37 oleanolic acid
-
Homo sapiens
3.4.21.37 piefeltarraenin IA
-
Homo sapiens
3.4.21.37 shionone
-
Homo sapiens
3.4.21.37 sivelestat sodium hydrate ONO-5046, selective inhibitor Homo sapiens
3.4.21.37 toosendanin
-
Homo sapiens
3.4.21.37 ursolic acid highest inhibitory potency Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.37 30000
-
x * 30000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 Elastin + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 leukocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 Elastin + H2O
-
Homo sapiens ?
-
?
3.4.21.37 methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
?

Subunits

EC Number Subunits Comment Organism
3.4.21.37 ? x * 30000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 HNE
-
Homo sapiens
3.4.21.37 neutrophil elastase
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.37 0.00551
-
pH and temperature not specified in the publication Homo sapiens ursolic acid