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Literature summary extracted from

  • Personne, Y.; Brown, A.; Schuessler, D.; Parish, T.
    Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities (2013), PLoS ONE, 8, e60228.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.92 Mycobacterium tuberculosis P9WPC5 protease subunit ClpP1
-
3.4.21.92 Mycobacterium tuberculosis P9WPC3 protease subunit ClpP2
-
3.4.21.92 Mycobacterium tuberculosis H37Rv P9WPC5 protease subunit ClpP1
-
3.4.21.92 Mycobacterium tuberculosis H37Rv P9WPC3 protease subunit ClpP2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.92 LacZ + H2O
-
 Mycobacterium tuberculosis ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
3.4.21.92 LacZ + H2O
-
 Mycobacterium tuberculosis H37Rv ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
3.4.21.92 additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis ?
-
 ?
3.4.21.92 additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis H37Rv ?
-
 ?
3.4.21.92 SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis ?
-
 ?
3.4.21.92 SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.92 ATP-dependent Clp protease proteolytic subunit 1
-
 Mycobacterium tuberculosis
3.4.21.92 ATP-dependent Clp protease proteolytic subunit 2
-
 Mycobacterium tuberculosis
3.4.21.92 ClpP1
-
 Mycobacterium tuberculosis
3.4.21.92 ClpP2
-
 Mycobacterium tuberculosis

Expression

EC Number Organism Comment Expression
3.4.21.92 Mycobacterium tuberculosis proteolytic subunits ClpP1 and ClpP2 are co-expressed under normal growth conditions with a single promoter region for the clpP1P2 operon additional information