Literature summary extracted from
Salzberg, Y.; Ramirez-Suarez, N.J.; Buelow, H.E.
The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans (2014), PLoS Genet., 10, e1004657.
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.21.75 |
Caenorhabditis elegans |
O17798 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.4.21.75 |
KPC-1 |
- |
Caenorhabditis elegans |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.4.21.75 |
physiological function |
the enzyme is necessary to promote the formation of higher order dendritic branches in PVD mechanosensory neurons and to ensure self-avoidance of sister branches, but is likely not required during maintenance of dendritic arbors. The enzyme also regulates the development of other neurons in all major neuronal classes in Caenorhabditis elegans, including aspects of branching and extension of neurites as well as cell positioning. The enzyme functions in a pathway with MNR-1/menorin, SAX-7/L1CAM and DMA-1 to control dendritic branch formation and extension of PVD neurons. The enzyme acts in concert with the menorin pathway to control branching and growth of somatosensory dendrites in PVD |
Caenorhabditis elegans |