EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.26 | (1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid | 81.9% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid | 88% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | 93.8% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid | 29.4% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (2E)-3-(4-methoxyphenyl)prop-2-enoic acid | less than 10% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (2E)-3-phenylprop-2-enoic acid | 16.1% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid | 72.9% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | 88.3% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (E)-1-(3-(4-methoxyphenyl)acryloyl)pyrrolidine-2-carboxylic acid | less than 10% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (E)-4-(3-(2-(methoxycarbonyl)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-1,2-phenylene-diacetate | 98.3% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (E)-methyl 1-(3-(3,4-dihydroxyphenyl)acryloyl)pyrrolidine-2-carboxylate | 96.3% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (E)-methyl 1-(3-(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4,5-trihydroxycyclohexanecarbonyl)pyrrolidine-2-carboxylate | 75.5% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | (E)-methyl 1-(3-(4-methoxyphenyl)acryloyl)pyrrolidine-2-carboxylate | 42.8% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | 1-cinnamoylpyrrolidine-2-carboxylic acid | 14.6% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate | - |
Homo sapiens | |
3.4.21.26 | methyl (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylate | 92.6% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | 90.5% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | methyl (2E)-3-(4-methoxyphenyl)prop-2-enoate | 22% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | methyl (2E)-3-phenylprop-2-enoate | 20% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | methyl 1-cinnamoylpyrrolidine-2-carboxylate | less than 10% inhibition at 0.5 mM | Homo sapiens | |
3.4.21.26 | verbascoside | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.26 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.26 | benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.26 | POP | - |
Homo sapiens |
3.4.21.26 | post-proline cleaving enzyme | - |
Homo sapiens |
3.4.21.26 | prolyl endopeptidase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.4.21.26 | 0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylate | |
3.4.21.26 | 0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | verbascoside | |
3.4.21.26 | 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
3.4.21.26 | 0.0125 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | |
3.4.21.26 | 0.0143 | - |
pH and temperature not specified in the publication | Homo sapiens | (5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | |
3.4.21.26 | 0.023 | - |
pH and temperature not specified in the publication | Homo sapiens | (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid | |
3.4.21.26 | 0.028 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid | |
3.4.21.26 | 0.0989 | - |
pH and temperature not specified in the publication | Homo sapiens | (1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid | |
3.4.21.26 | 0.1057 | - |
pH and temperature not specified in the publication | Homo sapiens | (E)-methyl 1-(3-(3,4-dihydroxyphenyl)acryloyl)pyrrolidine-2-carboxylate | |
3.4.21.26 | 0.12 | - |
pH and temperature not specified in the publication | Homo sapiens | (E)-4-(3-(2-(methoxycarbonyl)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-1,2-phenylene-diacetate | |
3.4.21.26 | 0.198 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid | |
3.4.21.26 | 0.21 | - |
pH and temperature not specified in the publication | Homo sapiens | (E)-methyl 1-(3-(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4,5-trihydroxycyclohexanecarbonyl)pyrrolidine-2-carboxylate | |
3.4.21.26 | 4.9 | - |
pH and temperature not specified in the publication | Homo sapiens | benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate |