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Literature summary extracted from
- Prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases (2013), Neuroscience, 242, 140-150.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | KYP-2047 | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-synuclein + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | beta-amyloid + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | additional information | Homo sapiens | prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases | ? | - |
? | |
| 3.4.21.26 | tau protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | - |
Homo sapiens | - |
| 3.4.21.26 | hippocampus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-synuclein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | beta-amyloid + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | N-carbobenzoxy-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-carbobenzoxy-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| 3.4.21.26 | tau protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | PEP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | PREP | - |
Homo sapiens |
| 3.4.21.26 | prolyl endopeptidase | - |
Homo sapiens |
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