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Literature summary extracted from

  • Nowicki, E.M.; OBrien, J.P.; Brodbelt, J.S.; Trent, M.S.
    Characterization of Pseudomonas aeruginosa LpxT reveals dual positional lipid A kinase activity and co-ordinated control of outer membrane modification (2014), Mol. Microbiol., 94, 728-741.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.29 additional information modulation of LpxTPa activity is influenced by transcription of the lipid A aminoarabinose transferase ArnT Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.29 Mg2+ limiting Mg2+ during growth results in inhibition of enzyme LpxT activity. Modulation is independent of transcription Pseudomonas aeruginosa
2.7.4.29 additional information modulation of LpxTPa activity is influenced by transcription of the lipid A aminoarabinose transferase ArnT Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.29 Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.29 ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
 Pseudomonas aeruginosa ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate phosphate modification of lipid A can occur both at the 1-phosphate and the 4'-phosphate groups ?
2.7.4.29 ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
 Pseudomonas aeruginosa ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 4'-diphosphate phosphate modification of lipid A can occur both at the 1-phosphate and the 4'-phosphate groups ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.29 LptX
-
 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
2.7.4.29 physiological function a chromosomal deletion mutant cannot phosphorylate lipid A Pseudomonas aeruginosa