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Literature summary extracted from

  • Ayers, B.J.; Glawar, A.F.; Martinez, R.F.; Ngo, N.; Liu, Z.; Fleet, G.W.; Butters, T.D.; Nash, R.J.; Yu, C.Y.; Wormald, M.R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S.F.
    Nine of 16 stereoisomeric polyhydroxylated proline amides are potent beta-N-acetylhexosaminidase inhibitors (2014), J. Org. Chem., 79, 3398-3409.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-allonamide
-
 Aspergillus oryzae
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-allonamide
-
 Homo sapiens
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-mannonamide
-
 Aspergillus oryzae
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-mannonamide
-
 Homo sapiens
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-talonamide
-
 Aspergillus oryzae
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-D-talonamide
-
 Homo sapiens
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-L-gulonamide
-
 Aspergillus oryzae
3.2.1.53 methyl 2,5-dideoxy-2,5-imino-L-gulonamide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.53 Aspergillus oryzae
-
-
-
3.2.1.53 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.53 commercial preparation
-
 Homo sapiens
-
3.2.1.53 commercial preparation
-
 Aspergillus oryzae
-
3.2.1.53 HL-60 cell
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.53 0.00035
-
 pH 4.5, 37°C Aspergillus oryzae methyl 2,5-dideoxy-2,5-imino-D-mannonamide
3.2.1.53 0.001
-
 pH 4.5, 37°C Homo sapiens methyl 2,5-dideoxy-2,5-imino-D-mannonamide
3.2.1.53 0.0028
-
 pH 4.5, 37°C Homo sapiens methyl 2,5-dideoxy-2,5-imino-D-allonamide
3.2.1.53 0.0036
-
 pH 4.5, 37°C Homo sapiens methyl 2,5-dideoxy-2,5-imino-D-talonamide
3.2.1.53 0.0073
-
 pH 4.5, 37°C Aspergillus oryzae methyl 2,5-dideoxy-2,5-imino-L-gulonamide
3.2.1.53 0.0095
-
 pH 4.5, 37°C Aspergillus oryzae methyl 2,5-dideoxy-2,5-imino-D-allonamide
3.2.1.53 0.025
-
 pH 4.5, 37°C Aspergillus oryzae methyl 2,5-dideoxy-2,5-imino-D-talonamide
3.2.1.53 0.026
-
 pH 4.5, 37°C Homo sapiens methyl 2,5-dideoxy-2,5-imino-L-gulonamide