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Literature summary extracted from

  • Yoon, H.; Radulovic, M.; Wu, J.; Blaber, S.I.; Blaber, M.; Fehlings, M.G.; Scarisbrick, I.A.
    Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity (2013), J. Neurochem., 127, 283-298.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B10 quantitative PCR-based enzyme expression analysis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B10 proform protease activated receptor 1 + H2O Mus musculus
-
 mature protease activated receptor 1 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 1 + H2O Mus musculus C57/BL6J
-
 mature protease activated receptor 1 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 2 + H2O Mus musculus
-
 mature protease activated receptor 2 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 2 + H2O Mus musculus C57/BL6J
-
 mature protease activated receptor 2 + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B10 Mus musculus
-
-
-
3.4.21.B10 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B10 additional information quantitative PCR-based enzyme expression analysis in spinal cord injury, overview Mus musculus
-
3.4.21.B10 neuron primary cerebellar granule neuron and NSC34 spinal cord motoneuron cell culture Mus musculus
-
3.4.21.B10 NSC-34 cell
-
 Mus musculus
-
3.4.21.B10 spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B10 proform protease activated receptor 1 + H2O
-
 Mus musculus mature protease activated receptor 1 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 1 + H2O
-
 Mus musculus C57/BL6J mature protease activated receptor 1 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 2 + H2O
-
 Mus musculus mature protease activated receptor 2 + ?
-
 ?
3.4.21.B10 proform protease activated receptor 2 + H2O
-
 Mus musculus C57/BL6J mature protease activated receptor 2 + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B10 kallikrein 6
-
 Mus musculus
3.4.21.B10 KLK6
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.21.B10 malfunction ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line is reduced by lipopeptide inhibitors of PAR1 or PAR2, and PAR1 genetic deletion, which reduces the neurotoxic effects of the enzyme Mus musculus
3.4.21.B10 metabolism kallikrein 6 and thrombin are important regulators of neural pathophysiology and neurotoxic Mus musculus
3.4.21.B10 additional information Klk6 and the prototypical activator of protease activated receptor 1, PAR1, thrombin, as well as PAR1 and PAR2, are each elevated in murine experimental traumatic spinal cord injury at acute or subacute time points Mus musculus
3.4.21.B10 physiological function kallikrein 6 is a serine protease implicated in neurodegeneration. Kallikrein 6 elicits ERK1/2 signaling in neurons by activation of protease activated receptors PAR1 and PAR2. Recombinant Klk6 triggered ERK1/2 signaling in cerebellar granule neurons and in the NSC34 spinal cord motoneuron cell line, in a PI3K and MEK-dependent fashion. Kallikrein 6 and thrombin promote degeneration of cerebellar neurons and exacerbate glutamate neurotoxicity Mus musculus