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Literature summary extracted from

  • Lu, W.D.; Funkelstein, L.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
    Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters (2012), J. Neurochem., 122, 512-522.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.16 additional information amastatin, arphamenine A, and bestatin have no effect on cathepsin H Bos taurus
3.4.22.16 additional information amastatin, arphamenine A, and bestatin have no effect on cathepsin H Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.16 secretory vesicle
-
 Mus musculus 99503
-
3.4.22.16 secretory vesicle
-
 Bos taurus 99503
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.16 28000
-
 x * 28000, SDS-PAGE Mus musculus
3.4.22.16 28000
-
 x * 28000, SDS-PAGE Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Bos taurus
-
-
-
3.4.22.16 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.16 adrenal medulla
-
 Bos taurus
-
3.4.22.16 brain
-
 Mus musculus
-
3.4.22.16 chromaffin cell
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.16 L-Arg-7-amido-4-methylcoumarin + H2O best substrate Mus musculus L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 L-Arg-7-amido-4-methylcoumarin + H2O best substrate Bos taurus L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 L-Lys-7-amido-4-methylcoumarin + H2O best substrate Mus musculus L-Lys + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 L-Lys-7-amido-4-methylcoumarin + H2O best substrate Bos taurus L-Lys + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 Lys-Arg-(Met)enkephalin + H2O
-
 Mus musculus Lys-Arg + (Met)enkephalin
-
 ?
3.4.22.16 Lys-Arg-(Met)enkephalin + H2O
-
 Bos taurus Lys-Arg + (Met)enkephalin
-
 ?
3.4.22.16 Lys-Lys-(Met)enkephalin + H2O
-
 Mus musculus Lys-Lys + (Met)enkephalin
-
 ?
3.4.22.16 Lys-Lys-(Met)enkephalin + H2O
-
 Bos taurus Lys-Lys + (Met)enkephalin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.16 ? x * 28000, SDS-PAGE Mus musculus
3.4.22.16 ? x * 28000, SDS-PAGE Bos taurus

General Information

EC Number General Information Comment Organism
3.4.22.16 malfunction knockout of the cathepsin H gene results in 50% reduction of (Met)enkephalin in mouse brain. Cathepsin H deficient mice also show a substantial 80% decrease in galanin peptide neurotransmitter levels in brain Mus musculus
3.4.22.16 physiological function cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production Mus musculus
3.4.22.16 physiological function cathepsin H plays a role in enkephalin and galanin peptide neurotransmitter production Bos taurus