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Literature summary extracted from

  • Nithipatikom, K.; Endsley, M.P.; Pfeiffer, A.W.; Falck, J.R.; Campbell, W.B.
    A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol (2014), J. Lipid Res., 55, 2093-2102.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.9 10-hydroxystearamide
-
 Homo sapiens
3.3.2.9 3-(decylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
3.3.2.9 3-(dodecylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
3.3.2.9 3-(octylthio)-1,1,1-trifluoropropan-2-one moderate inhibition Homo sapiens
3.3.2.9 methoxyarachidonyl fluorophosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3.2.9 0.042
-
 2-arachidonoylglycerol at pH 7.4 and 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.9 cis-stilbene oxide + H2O Homo sapiens
-
 (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 Hep-G2 cell
-
 Homo sapiens
-
3.3.2.9 LNCaP cell
-
 Homo sapiens
-
3.3.2.9 PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 2-arachidonoylglycerol + H2O
-
 Homo sapiens arachidonic acid + glycerol
-
 ?
3.3.2.9 cis-stilbene oxide + H2O
-
 Homo sapiens (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?
3.3.2.9 additional information no activity with 14,15-epoxyexicosatrienoic acid Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.9 EPHX1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.9 0.0000079
-
 at pH 7.4 and 37°C Homo sapiens methoxyarachidonyl fluorophosphate

General Information

EC Number General Information Comment Organism
3.3.2.9 metabolism the enzyme plays a role in the endocannabinoid signaling and a new arachidonic acid biosynthetic pathway Homo sapiens