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Literature summary extracted from

  • Qi, Y.; Zuo, Y.; Yeh, E.T.; Cheng, J.
    An essential role of small ubiquitin-like modifier (SUMO)-specific protease 2 in myostatin expression and myogenesis (2014), J. Biol. Chem., 289, 3288-3293.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.B71 nucleus
-
 Mus musculus 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.B71 SUMOylated myocyte-specific enhancer factor-2A + H2O Mus musculus deSUMOylation by enzyme SENP2 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?
3.4.22.B71 SUMOylated myocyte-specific enhancer factor-2A + H2O Mus musculus C57BL/6 deSUMOylation by enzyme SENP2 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B71 Mus musculus
-
-
-
3.4.22.B71 Mus musculus C57BL/6
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.B71 C2C12 cell
-
 Mus musculus
-
3.4.22.B71 embryo
-
 Mus musculus
-
3.4.22.B71 heart
-
 Mus musculus
-
3.4.22.B71 MEF cell
-
 Mus musculus
-
3.4.22.B71 additional information correlation of Senp2 and myostatin expression in cachexia Mus musculus
-
3.4.22.B71 satellite stem cell isolated from skeletal muscle Mus musculus
-
3.4.22.B71 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B71 SUMOylated myocyte-specific enhancer factor-2A + H2O deSUMOylation by enzyme SENP2 Mus musculus deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?
3.4.22.B71 SUMOylated myocyte-specific enhancer factor-2A + H2O deSUMOylation by enzyme SENP2 Mus musculus C57BL/6 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B71 small ubiquitin-like modifier-specific protease 2
-
 Mus musculus
3.4.22.B71 SUMO-specific protease 2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.B71 additional information Correlation of Senp2 and myostatin expression in cachexia Mus musculus
3.4.22.B71 physiological function the broad deSUMOylation activity of the enzyme in vitro is essential for embryonic heart development, essential role of small ubiquitin-like modifier-specific protease 2 in myostatin expression and myogenesis, overview. Enzyme SENP2 regulates the transcription of myostatin mainly through deSUMOylation of MEF2A. MEF2A mediates SENP2 activity on the myostatin promoter involving the MEF2 binding site. Enzyme SENP2 inhibits skeletal myogenesis Mus musculus