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Literature summary extracted from
- Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies (2014), J. Biol. Chem., 289, 19383-19394.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.22.B25 | gene Capn5, DNA and amino acid sequence determination and analysis | Mus musculus |
| 3.4.22.B25 | gene Capn5, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis | Rattus norvegicus |
| 3.4.22.B25 | gene Capn5, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.22.B25 | additional information | unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme CAPN5 is associated with one or more nuclear bodies. Non-nuclear, particularly perinuclear. CAPN5 is found in punctate domains associated with promyelocytic leukemia protein within the nucleus | Homo sapiens | - |
- |
| 3.4.22.B25 | additional information | unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies | Rattus norvegicus | - |
- |
| 3.4.22.B25 | additional information | unlike findings in classical calpains, which are characterized as being mainly cytosolic, CAPN5 is predominantly a noncytosolic calpain, present in the nucleus in the nucleic acidbinding protein fraction. The enzyme is associated with nuclear promyelocytic leukemia protein bodies | Mus musculus | - |
- |
| 3.4.22.B25 | nucleus | the enzyme carries dual nuclear localization signals | Rattus norvegicus | 5634 | - |
| 3.4.22.B25 | nucleus | the enzyme carries dual nuclear localization signals | Mus musculus | 5634 | - |
| 3.4.22.B25 | nucleus | the enzyme carries the nuclear localization signal RRRK (aa 2124) | Homo sapiens | 5634 | - |
| 3.4.22.B25 | perinuclear space | - |
Rattus norvegicus | - |
- |
| 3.4.22.B25 | perinuclear space | - |
Mus musculus | - |
- |
| 3.4.22.B25 | perinuclear space | - |
Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.B25 | Ca2+ | dependent on | Rattus norvegicus |  |
| 3.4.22.B25 | Ca2+ | dependent on | Mus musculus | |
| 3.4.22.B25 | Ca2+ | dependent on | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.B25 | Homo sapiens | O15484 | - |
- |
| 3.4.22.B25 | Mus musculus | O08688 | gene Capn5 | - |
| 3.4.22.B25 | Mus musculus C57/BL6J | O08688 | gene Capn5 | - |
| 3.4.22.B25 | Rattus norvegicus | Q8R4C0 | gene Capn5 | - |
| 3.4.22.B25 | Rattus norvegicus Sprague-Dawley | Q8R4C0 | gene Capn5 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.B25 | astrocyte | - |
Mus musculus | - |
| 3.4.22.B25 | brain | - |
Rattus norvegicus | - |
| 3.4.22.B25 | brain | - |
Mus musculus | - |
| 3.4.22.B25 | central nervous system | - |
Mus musculus | - |
| 3.4.22.B25 | central nervous system | - |
Homo sapiens | - |
| 3.4.22.B25 | central nervous system | high expression level | Rattus norvegicus | - |
| 3.4.22.B25 | dentate granule cell | - |
Mus musculus | - |
| 3.4.22.B25 | hilar neuron | - |
Mus musculus | - |
| 3.4.22.B25 | hippocampus | - |
Mus musculus | - |
| 3.4.22.B25 | additional information | immunohistochemic analysis, ubiquitous expression in central nerous system cells, overview | Mus musculus | - |
| 3.4.22.B25 | neuroblastoma cell | - |
Homo sapiens | - |
| 3.4.22.B25 | oligodendrocyte | - |
Mus musculus | - |
| 3.4.22.B25 | pyramidal neuron | - |
Mus musculus | - |
| 3.4.22.B25 | SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.22.B25 | CAPN5 | - |
Rattus norvegicus |
| 3.4.22.B25 | CAPN5 | - |
Mus musculus |
| 3.4.22.B25 | CAPN5 | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.22.B25 | evolution | calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain | Rattus norvegicus |
| 3.4.22.B25 | evolution | calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain | Mus musculus |
| 3.4.22.B25 | evolution | calpain 5 is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and Ca2 binding domains, and it contains a unique C-terminal domain | Homo sapiens |
| 3.4.22.B25 | additional information | the enzyme is associated with nuclear promyelocytic leukemia protein bodies | Rattus norvegicus |
| 3.4.22.B25 | additional information | the enzyme is associated with nuclear promyelocytic leukemia protein bodies | Mus musculus |
| 3.4.22.B25 | additional information | the enzyme is associated with nuclear promyelocytic leukemia protein bodies | Homo sapiens |
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Release 2023.1 (January 2023)
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