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Literature summary extracted from

  • Johnson, E.S.; Lindblom, K.R.; Robeson, A.; Stevens, R.D.; Ilkayeva, O.R.; Newgard, C.B.; Kornbluth, S.; Andersen, J.L.
    Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis (2013), J. Biol. Chem., 288, 14463-14475.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.55 palmitate caspase-2 is activated by an overabundance of saturated long-chain fatty acids like palmitate. Inhibition of amino acid transamination by 10 mM aminooxyacetate blocks caspase activation Xenopus laevis

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.55 Xenopus laevis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.55 egg
-
 Xenopus laevis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.55 N-acetyl-DEVD-4-nitroanilide + H2O
-
 Xenopus laevis N-acetyl-DEVD + 4-nitroaniline
-
 ?

General Information

EC Number General Information Comment Organism
3.4.22.55 physiological function caspase-2 plays a role in lipoapoptosis and is required for cell death Xenopus laevis