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Literature summary extracted from

  • Funkelstein, L.; Lu, W.D.; Koch, B.; Mosier, C.; Toneff, T.; Taupenot, L.; O'Connor, D.T.; Reinheckel, T.; Peters, C.; Hook, V.
    Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters (2012), J. Biol. Chem., 287, 15232-15241.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.43 secretory vesicle
-
 Homo sapiens 99503
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.43 24000
-
 x * 24000, mature enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.43 neuropeptide Y + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.43 proenkephalin + H2O Homo sapiens
-
 (Met)enkephalin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.43 Homo sapiens O60911
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.43 brain cortex
-
 Homo sapiens
-
3.4.22.43 hippocampus
-
 Homo sapiens
-
3.4.22.43 PC-12 cell
-
 Homo sapiens
-
3.4.22.43 SK-N-MC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.43 Boc-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.43 neuropeptide Y + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.43 proenkephalin + H2O
-
 Homo sapiens (Met)enkephalin + ?
-
 ?
3.4.22.43 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Z-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.43 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.43 ? x * 24000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.22.43 cathepsin V
-
 Homo sapiens
3.4.22.43 CTSV also known as CTSL2 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.22.43 metabolism cathepsin V participates in the production of enkephalin and neuropeptide Y neurotransmitters in secretory vesicles Homo sapiens