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Literature summary extracted from

  • Lee, I.; Bae, K.; Kuk Yoo, J.; Ryoo, I.; Kim, B.; Seog Ahn, J.; Yoo, I.
    Inhibition of human neutrophil elastase by ergosterol derivatives from the mycelium of Phellinus linteus (2012), J. Antibiot., 65, 437-440.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 (22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol
-
 Homo sapiens
3.4.21.37 (3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide
-
 Homo sapiens
3.4.21.37 (3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside
-
 Homo sapiens
3.4.21.37 14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione
-
 Homo sapiens
3.4.21.37 3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one
-
 Homo sapiens
3.4.21.37 3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene
-
 Homo sapiens
3.4.21.37 3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one
-
 Homo sapiens
3.4.21.37 3beta-hydroxy-ergosta-7,22-dien-6-one
-
 Homo sapiens
3.4.21.37 5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol
-
 Homo sapiens
3.4.21.37 5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol
-
 Homo sapiens
3.4.21.37 5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol
-
 Homo sapiens
3.4.21.37 epigallocatechin gallate
-
 Homo sapiens
3.4.21.37 ergosta-4,7,22-trien-3,6-dione
-
 Homo sapiens
3.4.21.37 ergosta-7,22-dien-2beta,3alpha,9alpha-triol
-
 Homo sapiens
3.4.21.37 ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol
-
 Homo sapiens
3.4.21.37 ergosterol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 Elastin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 Elastin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 HNE
-
 Homo sapiens
3.4.21.37 neutrophil elastase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.37 0.0146
-
 pH 7.5, 37°C Homo sapiens 3beta,5alpha-dihydroxy-6beta-methoxyergosta-7,22-diene
3.4.21.37 0.0205
-
 pH 7.5, 37°C Homo sapiens 14alpha-hydroxy-ergosta-4,7,9(11),22-tetraen-3,6-dione
3.4.21.37 0.0282
-
 pH 7.5, 37°C Homo sapiens 5alpha,6alpha-epoxy-ergosta-8(14),22-diene-3beta,7alpha-diol
3.4.21.37 0.0352
-
 pH 7.5, 37°C Homo sapiens 5alpha,6alpha,8alpha,9alpha-diepoxy-ergost-22-en-3beta,7alpha-diol
3.4.21.37 0.0552
-
 pH 7.5, 37°C Homo sapiens ergosta-4,7,22-trien-3,6-dione
3.4.21.37 0.0645
-
 pH 7.5, 37°C Homo sapiens ergosterol
3.4.21.37 0.0751
-
 pH 7.5, 37°C Homo sapiens 5alpha,6alpha-epoxy-ergosta-8(9),22-dien-7-one-3beta-ol
3.4.21.37 0.0775
-
 pH 7.5, 37°C Homo sapiens ergosta-7,22-dien-3beta,5alpha,6beta,9alpha-tetraol
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens (3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens (3beta,5alpha,8alpha,22E)-ergosta-6,22-diene-3-ol-5,8-peroxide 3-O-beta-D-glucoside
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens (22E,24R)-ergosta-7,22-dien-2alpha,3alpha,9alpha-triol
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens 3beta-hydroxy-ergosta-7,22-dien-6-one
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens 3beta,5alpha-dihydroxy-ergosta-7,22-dien-6-one
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens 3beta,5alpha,9alpha-trihydroxy-ergosta-7,22-dien-6-one
3.4.21.37 0.1
-
 IC50 above 0.1 mM, pH 7.5, 37°C Homo sapiens ergosta-7,22-dien-2beta,3alpha,9alpha-triol