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Literature summary extracted from

  • Garner, A.L.; Fullagar, J.L.; Day, J.A.; Cohen, S.M.; Janda, K.D.
    Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors (2013), J. Am. Chem. Soc., 135, 10014-10017.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.13 1,2-diethyl-3-hydroxypyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 1-ethyl-3-hydroxy-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 1-[2-(3-bromophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 1-[2-(3-chloro-4-methoxyphenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 1-[2-(3-chlorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 1-[2-(3-fluorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 3-hydroxy-1-[2-(3-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 3-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 3-hydroxy-2-methyl-1-(2-phenylethyl)pyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 3-hydroxy-2-methyl-1-[2-(3-methylphenyl)ethyl]pyridine-4(1H)-thione
-
Streptococcus pneumoniae
3.4.24.13 Berberine
-
Streptococcus pneumoniae
3.4.24.13 norharmane
-
Streptococcus pneumoniae
3.4.24.13 remerine
-
Streptococcus pneumoniae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.13 extracellular
-
Streptococcus pneumoniae
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.13 Zn2+ contains zinc Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.13 immunoglobulin A1 + H2O Streptococcus pneumoniae
-
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.13 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.13 immunoglobulin A1 + H2O
-
Streptococcus pneumoniae immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.13 IgA1P
-
Streptococcus pneumoniae
3.4.24.13 immunoglobulin A1 protease
-
Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.13 0.0043
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1-[2-(3-chlorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
3.4.24.13 0.00498
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1-[2-(3-chloro-4-methoxyphenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
3.4.24.13 0.00614
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1-[2-(3-bromophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
3.4.24.13 0.00664
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 3-hydroxy-1-[2-(3-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione
3.4.24.13 0.007
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 3-hydroxy-1-[2-(4-methoxyphenyl)ethyl]-2-methylpyridine-4(1H)-thione
3.4.24.13 0.00774
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1-[2-(3-fluorophenyl)ethyl]-3-hydroxy-2-methylpyridine-4(1H)-thione
3.4.24.13 0.00914
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 3-hydroxy-2-methyl-1-[2-(3-methylphenyl)ethyl]pyridine-4(1H)-thione
3.4.24.13 0.0127
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 3-hydroxy-2-methyl-1-(2-phenylethyl)pyridine-4(1H)-thione
3.4.24.13 0.0231
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae remerine
3.4.24.13 0.0523
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae Berberine
3.4.24.13 0.152
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae norharmane
3.4.24.13 0.887
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1-ethyl-3-hydroxy-2-methylpyridine-4(1H)-thione
3.4.24.13 0.962
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 1,2-diethyl-3-hydroxypyridine-4(1H)-thione
3.4.24.13 1.3
-
in 50 mM Tris-HCl, pH 7.0, at 37°C Streptococcus pneumoniae 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione

General Information

EC Number General Information Comment Organism
3.4.24.13 physiological function the enzyme catalyzes the proteolysis of human IgA1 at its hinge region to leave the bacterial cell surface masked by IgA1 Fab, enabling the bacteria to evade the host's immune system and adhere to host epithelial cells to promote colonization Streptococcus pneumoniae