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Literature summary extracted from

  • Kosanovic, D.; Dahal, B.K.; Wygrecka, M.; Reiss, I.; Guenther, A.; Ghofrani, H.A.; Weissmann, N.; Grimminger, F.; Seeger, W.; Schermuly, R.T.; Banat, G.A.
    Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis? (2013), Histol. Histopathol., 28, 691-699.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.39 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + His-Leu
-
 ?
3.4.21.39 endothelin-1 + H2O Rattus norvegicus
-
 31 amino-acid fragment of ET-1 + ?
-
 ?
3.4.21.39 interleukin-18 + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.21.39 interleukin-1beta + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.21.39 procollagen + H2O Rattus norvegicus
-
 collagen + ?
-
 ?
3.4.21.39 transforming growth factor beta-binding protein + H2O Rattus norvegicus
-
 transforming growth factor beta + protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 mast cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + His-Leu
-
 ?
3.4.21.39 endothelin-1 + H2O
-
 Rattus norvegicus 31 amino-acid fragment of ET-1 + ?
-
 ?
3.4.21.39 interleukin-18 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.21.39 interleukin-1beta + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.21.39 procollagen + H2O
-
 Rattus norvegicus collagen + ?
-
 ?
3.4.21.39 transforming growth factor beta-binding protein + H2O
-
 Rattus norvegicus transforming growth factor beta + protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.39 MC chymase
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.21.39 7 9
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.21.39 physiological function the enzyme is involved in the process of pulmonary fibrosis. The enzyme has a role in connecting matrix metalloproteinases (MMPs), particularly the gelatinases MMP-2 and MMP-9, to pulmonary fibrosis. Mast cell chymase by processing angiotensin II and transforming growth factor beta contributes to the development of idiopathic pulmonary fibrosis Rattus norvegicus