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Literature summary extracted from

  • Ma, Y.; Cao, W.; Wang, L.; Jiang, J.; Nie, H.; Wang, B.; Wei, X.; Ying, W.
    Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels (2014), Glia, 62, 943-955.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.6 cyclic ADP-ribose + H2O Mus musculus
-
 ADP-D-ribose
-
 ?
3.2.2.6 additional information Mus musculus CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells ?
-
 ?
3.2.2.6 NAD+ Mus musculus
-
 cyclic ADP-ribose + nicotinamide
-
 ?
3.2.2.6 NAD+ + H2O Mus musculus overall reaction ADP-D-ribose + nicotinamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.6 Mus musculus P56528
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.6 astrocyte
-
 Mus musculus
-
3.2.2.6 brain
-
 Mus musculus
-
3.2.2.6 BV-2 cell
-
 Mus musculus
-
3.2.2.6 microglia primary microglial cultures as cellular models Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.6 cyclic ADP-ribose + H2O
-
 Mus musculus ADP-D-ribose
-
 ?
3.2.2.6 additional information CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells Mus musculus ?
-
 ?
3.2.2.6 NAD+
-
 Mus musculus cyclic ADP-ribose + nicotinamide
-
 ?
3.2.2.6 NAD+ + H2O overall reaction Mus musculus ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.6 CD38
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.2.6 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.2.6 7.4
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.2.2.6 malfunction CD38 reductions lead to microglial apoptosis. inhibition of CD38/cADPR-dependent signaling by CD38 silencing or 8-bromo-cADPR, a ryanodine receptor antagonist, produced significant ATP release from BV2 microglia. Cx43 small interfering RNA and Cx43 hemichannel blocker 18-alpha-glycyrrhetinic acid completely prevented the CD38 silencing or 8-bromo-cADPR-induced ATP release. Prevention of the ATP release might also be due to P2X7 receptor antagonists. Key role of ATP release in the microglial apoptosis induced by decreased CD38/cADPR-dependent signaling, overview Mus musculus
3.2.2.6 physiological function CD38 is an ectoenzyme that consumes NAD+ to produce cyclic ADP-ribose, a potent agonist of ryanodine receptors. Basal CD38/cyclic ADP-ribose-dependent signaling plays a key role in ATP release, which mediates basal survival of microglia, overview Mus musculus