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Literature summary extracted from

  • Harris, T.R.; Hammock, B.D.
    Soluble epoxide hydrolase: gene structure, expression and deletion (2013), Gene, 526, 61-74.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.3.2.10 medicine because of its central physiological role in disease states such as cardiac hypertrophy, diabetes, hypertension, and pain, the enzym is used as a therapeutic target Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.3.2.10 K55R the mutant has reduced phosphatase activity compared to the wild type. The mutant is associated with the risk of developing coronary heart disease in Caucasians, but not African Americans Homo sapiens
3.3.2.10 R287Q the mutant has decreased epoxide hydrolase and phosphatase activity compared to the wild type. The mutant is associated with lower vascular resistance in response to bradykinin in black, but not white Americans Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 cytosol
-
 Homo sapiens 5829
-
3.3.2.10 microsome
-
 Homo sapiens
-
-
3.3.2.10 mitochondrion
-
 Homo sapiens 5739
-
3.3.2.10 peroxisome
-
 Homo sapiens 5777
-
3.3.2.10 soluble
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.10 62000
-
 2 * 62000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens P34913
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 adipose tissue
-
 Homo sapiens
-
3.3.2.10 brain
-
 Homo sapiens
-
3.3.2.10 heart
-
 Homo sapiens
-
3.3.2.10 kidney
-
 Homo sapiens
-
3.3.2.10 liver
-
 Homo sapiens
-
3.3.2.10 lung
-
 Homo sapiens
-
3.3.2.10 pulmonary artery
-
 Homo sapiens
-
3.3.2.10 theca cell
-
 Homo sapiens
-
3.3.2.10 vasculature
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoic acid + H2O
-
 Homo sapiens 14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 leukotoxin + H2O
-
 Homo sapiens leukotoxin-1,2-diol
-
 ?

Subunits

EC Number Subunits Comment Organism
3.3.2.10 homodimer 2 * 62000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.3.2.10 Homo sapiens there is a significant reduction in protein expression in renal and liver malignant neoplasms compared to healthy tissue down
3.3.2.10 Homo sapiens homocysteine significantly upregulates enzyme mRNA expression. PPARgamma activation is linked to enzyme expression in human endothelial cells. Angiotensin-II treatment of HUVECs results in an over 2fold increase in mRNA expression up

General Information

EC Number General Information Comment Organism
3.3.2.10 malfunction enzyme single nucleotide polymorphisms are associated with cardiovascular disease Homo sapiens
3.3.2.10 physiological function through its metabolism of the epoxyeicosatrienoic acids and other lipid mediators, the enzyme contributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response. The enzyme plays a role in either the initiation of corpus luteum formation, and/or in the regression of the structure. The enzyme is implicated in the pathology of pulmonary hypertension Homo sapiens