EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.26 | Z-prolyl-prolinal | - |
Homo sapiens | |
3.4.21.B28 | additional information | no inhibition by Z-Pro-prolinal | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.26 | soluble | - |
Homo sapiens | - |
- |
3.4.21.B28 | membrane | a type II integral membrane serine protease | Homo sapiens | 16020 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.26 | 80000 | - |
x * 80000 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.B28 | additional information | Homo sapiens | a post-proline cleaving serine peptidase | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.26 | Homo sapiens | - |
- |
- |
3.4.21.B28 | Homo sapiens | Q12844 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.B28 | epithelial carcinoma cell | - |
Homo sapiens | - |
3.4.21.B28 | additional information | the enzyme is not expressed in normal adult tissues, but is highly expressed on stromal fibroblasts in virtually all epithelial carcinomas and on tumor cells of some sarcomas | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.26 | GEPGPPGPA + H2O | - |
Homo sapiens | GEP + GPPGP + L-Ala | - |
? | |
3.4.21.26 | GFSPFRQED + H2O | - |
Homo sapiens | GFSP + FRQED | - |
? | |
3.4.21.26 | GTAGPNQEQE + H2O | - |
Homo sapiens | GTAGP + NQEQE | - |
? | |
3.4.21.26 | GTSGPNQEQE + H2O | - |
Homo sapiens | GTSGP + NQEQE | - |
? | |
3.4.21.26 | additional information | does not cleave GASGPAGPA | Homo sapiens | ? | - |
? | |
3.4.21.26 | RPKPQQFFGLM + H2O | - |
Homo sapiens | L-Arg-L-Pro + L-Lys-L-Pro + QQFFGLM | - |
? | |
3.4.21.26 | Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
3.4.21.B28 | alpha2-antiplasmin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B28 | GASGPAGPA + H2O | - |
Homo sapiens | GASGP + AGPA | - |
? | |
3.4.21.B28 | Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.B28 | GEPGPPGPA + H2O | - |
Homo sapiens | GEP + GPPGP + L-Ala | - |
? | |
3.4.21.B28 | GFSPFQRED + H2O | low activity | Homo sapiens | ? | - |
? | |
3.4.21.B28 | GTAGPNQEQE + H2O | - |
Homo sapiens | GTAGP + NQEQE | - |
? | |
3.4.21.B28 | GTSGPNQEQE + H2O | - |
Homo sapiens | GTSGP + NQEQE | - |
? | |
3.4.21.B28 | additional information | a post-proline cleaving serine peptidase | Homo sapiens | ? | - |
? | |
3.4.21.B28 | additional information | the enzyme exhibits post-proline cleaving dipeptidyl peptidase and endopeptidase activity toward gelatin and alpha2-antiplasmin. Substrate specificity analysis using a internally quenched fluorogenic probes library for screening, overview. The sequence Pro-Tyr-Asp is strongly cleaved by the enzyme, sequence specificity, detailed overview | Homo sapiens | ? | - |
? | |
3.4.21.B28 | RPKPQQFFGLM + H2O | the substance P-derived sequence is cleaved although it does not contain Gly-Pro | Homo sapiens | RPKP + L-Gln-L-Gln + FFGLM | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.26 | ? | x * 80000 | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.26 | POP | - |
Homo sapiens |
3.4.21.B28 | FAP | - |
Homo sapiens |
3.4.21.B28 | fibroblast activation protein alpha | - |
Homo sapiens |
3.4.21.B28 | seprase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.21.B28 | evolution | the enzyme exhibits similar substrate specificity and properties compared to prolyl oligopeptidase, EC 3.4.21.26, the latter is specifically inhibited by Z-Pro-prolinal, while the fibroblast activation protein alpha is not. In contrast to prolyl oligopeptidase, fibroblast activation protein alpha is not expressed in normal adult tissues. Substrate specificity preferences among these sequences include Pro-Phe-Thr, which is strongly cleaved by prolyl oligopeptidase, and Pro-Tyr-Asp, which is strongly cleaved by fibroblast activation protein alpha. Pro-Phe/Tyr-Asp/Glu sequences are extensively cleaved by both prolyl oligopeptidase and fibroblast activation protein alpha, but neither enzyme exhibit substantial cleavage of Pro-Asp/Glu-Phe-Tyr | Homo sapiens |