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Literature summary extracted from

  • Ataullakhanov, F.; Dashkevich, N.; Negrier, C.; Panteleev, M.
    Factor XI and traveling waves: The key to understanding coagulation in hemophilia? (2013), Expert Rev. Hematol., 6, 111-113.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.27 factor XIIa
-
 Homo sapiens
3.4.21.27 thrombin the enzyme can be activated, albeit slowly, by thrombin Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.27 factor IX + H2O Homo sapiens
-
 factor IXa + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 factor IX + H2O
-
 Homo sapiens factor IXa + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.27 factor XIa
-
 Homo sapiens
3.4.21.27 FXIa
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.27 malfunction factor XI deficiency can lead to delayed clot formation and decreased thrombin generation Homo sapiens
3.4.21.27 physiological function factor XI is important in the tissue factor-independent propagation phase of clot formation, not in the initiation process Homo sapiens