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Literature summary extracted from

  • Meng, H.; Liu, Y.; Zhai, Y.; Lai, L.
    Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase (2013), Eur. J. Med. Chem., 59, 160-167.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride
-
Homo sapiens
3.3.2.6 2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethanaminium chloride
-
Homo sapiens
3.3.2.6 2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethanaminium chloride
-
Homo sapiens
3.3.2.6 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid
-
Homo sapiens
3.3.2.6 5-hydroxytryptamine
-
Homo sapiens
3.3.2.6 bestatin
-
Homo sapiens
3.3.2.6 JMC08-4 i.e. 1,2-amino-3-[5-(benzyloxy)-1H-indol-3-yl] propanoic acid Homo sapiens
3.3.2.6 methyl 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
-
Homo sapiens
3.3.2.6 methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
-
Homo sapiens
3.3.2.6 additional information not inhibited by NI101, 2-(5-(benzyloxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(naphthalen-2-ylmethoxy)-1H-indol-3-yl)ethanaminiumchloride, 2-(5-(naphthalen-1-ylmethoxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(2-(4-(4-nitrophenoxy)phenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride, 2-(5-(2-(4-(2-nitrophenoxy)phenoxy)ethoxy)-1H-indol-3-yl) ethanaminium chloride, 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid, and 3-(2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl) ethylamino)propanoic acid Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zn2+ contains zinc Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.3.2.6 69000
-
x * 69000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens
-
leukotriene B4
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
Homo sapiens leukotriene B4
-
?

Subunits

EC Number Subunits Comment Organism
3.3.2.6 ? x * 69000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase
-
Homo sapiens
3.3.2.6 LTA4H
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.0024
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
3.3.2.6 0.0038
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoic acid
3.3.2.6 0.0042
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens bestatin
3.3.2.6 0.0076
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
3.3.2.6 0.015
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 2-(5-(2-(4-phenoxyphenoxy)ethoxy)-1H-indol-3-yl)ethanaminium chloride
3.3.2.6 0.0158
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens methyl 3-(2-(5-(3-phenoxybenzyloxy)-1H-indol-3-yl)ethylamino)propanoate
3.3.2.6 0.018
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens 2-(5-(4-phenylbenzyloxy)-1H-indol-3-yl)ethanaminium chloride
3.3.2.6 0.231
-
in 10 mM sodium phosphate, pH 7.4, at 37°C Homo sapiens JMC08-4